Indications for Ofloxacin Tablets:
Susceptible infections including acute bacterial exacerbation of chronic bronchitis (ABECB), community-acquired pneumonia, acute pelvic inflammatory disease (PID), acute, uncomplicated cervical and urethral gonorrhea, urethritis, cervicitis, uncomplicated cystitis, uncomplicated skin and skin structure, complicated UTIs, prostatitis. For ABECB and uncomplicated cystitis: reserve for those who have no alternative treatment options.
≥18yrs: Take with full glass water. Bronchitis, pneumonia, uncomplicated skin and skin structure: 400mg every 12 hours for 10 days. Urethritis, cervicitis: 300mg every 12 hours for 7 days. Gonorrhea: 400mg once as a single dose. PID: 400mg every 12 hours for 10–14 days. Uncomplicated cystitis due to E. coli or K. pneumoniae: 200mg every 12 hrs for 3 days. Other uncomplicated cystitis: 200mg every 12 hrs for 7 days. Complicated UTIs: 200mg every 12 hrs for 10 days. Prostatitis due to E. coli: 300mg every 12 hours for 6 weeks. Severe hepatic impairment: max 400mg/day. Renal impairment: CrCl 20–50mL/min: give normal dose (loading dose) and increase dosing interval to 24 hours. CrCl <20mL/min: give normal dose once (loading dose) then ½ normal dose and increase dosing interval to 24 hours.
<18yrs: not established.
Ofloxacin Tablets Warnings/Precautions:
Increased risk of disabling and potentially irreversible adverse reactions (including tendinitis/tendon rupture [esp. in patients >60yrs, or those with kidney, heart or lung transplants], peripheral neuropathy, or CNS/psychiatric effects); discontinue immediately if signs/symptoms occur. CNS disorders (eg, cerebral arteriosclerosis, epilepsy) that increase seizure risk. History of myasthenia gravis; avoid. History of QT prolongation, ventricular arrhythmias, proarrhythmic conditions (eg, bradycardia, acute myocardial ischemia), hypokalemia; avoid. Increased risk of aortic aneurysm and dissection (esp. in elderly); reserve use only if no alternatives in patients with history or risk of. Discontinue at 1st sign of skin rash, jaundice, any other hypersensitivity, hepatitis, or photosensitivity. Monitor blood glucose in diabetic patients; discontinue if hypoglycemia occurs. Renal or hepatic impairment. Maintain adequate hydration. May mask symptoms of syphilis; test for syphilis before treating gonorrhea then follow-up after 3mos. Monitor blood, renal, and hepatic function in prolonged use. Avoid excessive sun or UV light. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Ofloxacin Tablets Classification:
Ofloxacin Tablets Interactions:
Avoid drugs that prolong QT interval (eg, Class IA or Class III antiarrhythmics). Take at least 2hrs before or 2hrs after magnesium- or aluminum-containing antacids, sucralfate, metal cations, multivitamins containing zinc or iron, or didanosine (buffered forms). Increased risk of tendinitis/tendon rupture with corticosteroids. Severe hypoglycemia with antidiabetics (eg, insulin, glyburide); monitor. Increased seizure risk with concomitant NSAIDs. May be potentiated by probenecid. May potentiate cyclosporine, theophylline, warfarin, other drugs metabolized by CYP450; monitor. May cause false (+) urine screening results for opiates using commercially available immunoassays.
Nausea, headache, insomnia, female genital pruritus, dizziness, vaginitis, diarrhea, vomiting; tendinitis/tendon rupture, peripheral neuropathy, CNS effects, hypersensitivity reactions, hepatotoxicity, C. difficile-associated diarrhea, torsades de pointes, dysglycemia, phototoxicity, aortic aneurysm/dissection.
Formerly known under the brand name Floxin.