Multiple sclerosis:

Indications for OCREVUS:

Relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. Primary progressive MS.

Adult Dosage:

Screen for HBV infection and test for serum immunoglobulins prior to initiation. Premedicate with corticosteroid and antihistamine prior to each infusion; may consider antipyretic. Initially 300mg by IV infusion, followed by a second 300mg infusion 2 weeks later, then subsequently as one 600mg infusion every 6 months. For infusion rates, duration, and dose modifications: see full labeling.

Children Dosage:

Not established.

OCREVUS Contraindications:

Active HBV infection. History of life-threatening infusion reaction to Ocrevus.

OCREVUS Warnings/Precautions:

Monitor for infusion reactions during and at least 1hr after therapy completion; permanently discontinue if life-threatening infusion reactions occur; treat appropriately. Active infection: delay Ocrevus treatment until resolved. Discontinue if serious herpes infection occur; withhold until resolved. Withhold at first sign/symptom of progressive multifocal leukoencephalopathy (PML) and evaluate. HBV reactivation: screen all patients for HBV; if positive HBsAg/anti-HB results, do not administer Ocrevus. Monitor serum immunoglobulin levels during and after therapy, until B-cell repletion, and esp. during recurrent serious infections. Consider discontinuing therapy in those with opportunistic or recurrent serious infections, and if prolonged hypogammaglobulinemia requires IV immunoglobulin treatment. Increased risk of malignancy (including breast cancer). Complete all immunizations according to guidelines at least 4 weeks (for live or live-attenuated vaccines) or at least 2 weeks (for non-live vaccines) prior to initiation. Infants born to mothers treated during pregnancy: do not administer live or live-attenuated vaccines before confirming B-cell recovery; non-live vaccines may be given prior to recovery, but should consider assessment of vaccine immune response. Advise females of reproductive potential to use effective contraception during and for 6 months after the last dose. Pregnancy. Nursing mothers.

OCREVUS Classification:

CD20-directed cytolytic monoclonal antibody.

OCREVUS Interactions:

Concomitant live or live-attenuated vaccines: not recommended during treatment and until B-cell repletion. May interfere with the effectiveness of non-live vaccines. Additive immunosuppressive effects with other immunosuppressants; consider the duration and effects when switching from immunomodulators (eg, corticosteroids, daclizumab, fingolimod, natalizumab, teriflunomide, mitoxantrone).

Adverse Reactions:

Upper/lower respiratory tract infections, infusion reactions (eg, pruritus, rash, urticaria, erythema, bronchospasm, throat irritation, others), skin infections; herpes virus-associated infections.

Generic Drug Availability:

NO

How Supplied:

Single-dose vial (10mL)—1

Pricing for OCREVUS

10ml of 30mg/ml vial (Qty: 2)
Appx. price $36901
GoodRx