Nuzyra Injection

  • Bacterial infections

Nuzyra Injection Generic Name & Formulations

General Description

Omadacycline 100mg/vial; lyophilized pwd for IV infusion after reconstitution and dilution; contains sucrose.

Pharmacological Class

Tetracycline antibiotic.

See Also

How Supplied

Single-dose vials—10; Tabs—6, 30

Generic Availability


Nuzyra Injection Indications


Susceptible infections including community-acquired bacterial pneumonia (CABP), acute bacterial skin and skin structure infections (ABSSSI).

Nuzyra Injection Dosage and Administration


≥18yrs: Day 1: Initially 200mg IV over 60mins or 100mg IV over 30mins twice. Maintenance: 100mg IV over 30mins once daily. Treat for 7–14 days.


<8yrs: not recommended (see full labeling); <18yrs: not established.

Nuzyra Injection Contraindications

Not Applicable

Nuzyra Injection Boxed Warnings

Not Applicable

Nuzyra Injection Warnings/Precautions


Mortality imbalance in CABP; closely monitor response esp. those at higher risk (eg, >65yrs, comorbidities). Discontinue if allergic reaction occurs. Evaluate if diarrhea occurs; discontinue if C. difficile-associated diarrhea is suspected or confirmed. Advise females of reproductive potential to use effective contraception during treatment. Pregnancy (during 2nd & 3rd trimester): may cause permanent discoloration of the teeth or reversible inhibition of bone growth. Nursing mothers: not recommended (during and for 4 days after the last dose).

Nuzyra Injection Pharmacokinetics

See Literature

Nuzyra Injection Interactions


May need to reduce concomitant anticoagulant dose. Inj: do not give with multivalent cation-containing solutions (eg, Ca, Mg, Al) through same IV line. Tabs: after dosing, avoid food or drink (except water) for 2hrs; and avoid dairy, antacids, iron preparations, multivitamins for 4hrs.

Nuzyra Injection Adverse Reactions

Adverse Reactions

Nausea, vomiting, infusion site reactions, AST/ALT/GGT increased, hypertension, headache, diarrhea, insomnia, constipation; hypersensitivity reactions, C. difficile-associated diarrhea, tetracycline class effects (eg, photosensitivity, pseudotumor cerebri, increased BUN, azotemia, acidosis, hyperphosphatemia, pancreatitis); also Children (up to 8yrs of age): tooth discoloration, enamel hypoplasia, inhibition of bone growth.

Nuzyra Injection Clinical Trials

See Literature

Nuzyra Injection Note

Not Applicable

Nuzyra Injection Patient Counseling

See Literature