• Parenteral nutrition

Nutrilipid Generic Name & Formulations

General Description

Lipid content 0.2g/mL (refined soybean oil); emulsion for IV infusion; contains aluminum.

Pharmacological Class

Fatty acids.

How Supplied

Emulsion (250mL, 500mL)—1


Generic Availability


Mechanism of Action

Nutrilipid administered intravenously provides biologically utilizable source of calories and essential fatty acids. Fatty acids serve as an important substrate for energy production. The most common mechanism of action for energy production derived from fatty acid metabolism is beta oxidation. Fatty acids are important for membrane structure and function, precursors for bioactive molecules (such as prostaglandins), and as regulators of gene expression.

Nutrilipid Indications


To provide a source of calories and essential fatty acids for parenteral nutrition and as a source of essential fatty acids when a deficiency occurs when oral or enteral nutrition is not possible, insufficient, or contraindicated.

Nutrilipid Dosage and Administration

Adults and Children

Individualize. Dose based on patient’s energy requirements, body wt, tolerance, clinical status, age-related growth rate in children, and ability to eliminate and metabolize fat. Administer by IV infusion via peripheral or central line. Preterm and term infants to 10yrs: initially 1–2g/kg/day; max 3g/kg/day. Initiate rate at 0.05mL/min for the first 10–15mins; increase gradually to required rate after 15mins (max 0.75mL/kg/hr). 11–<17yrs: initially 1g/kg/day; max 2.5g/kg/day. Initiate rate at 0.05mL/min for the first 10–15mins; increase gradually to required rate after 15mins (max 0.5mL/kg/hr). ≥17yrs: initially 1–1.5g/kg/day; max 2.5g/kg/day. Initiate rate at 0.5mL/min for the first 15–30mins; increase gradually to required rate after 30mins (max 0.5mL/kg/hr). Usual infusion duration: 12–24 hours; may continue treatment based on patient’s clinical status. If serum triglycerides (>400mg/dL): initiate at a lower dose and increase in smaller increments; check levels before each adjustment. For complete parenteral nutrition: supplement with amino acids, carbohydrates, electrolytes, vitamins and trace elements.

Nutrilipid Contraindications


Egg, soybean, or peanut allergy. Severe disorders of lipid metabolism characterized by hypertriglyceridemia (serum triglyceride >1000mg/dL).

Nutrilipid Boxed Warnings

Not Applicable

Nutrilipid Warnings/Precautions


Clinical decompensation with rapid IV infusion in neonates/infants. Risk of parenteral nutrition-associated liver disease (eg, cholestasis or hepatic steatosis), other hepatobiliary disorders (eg, cholecystitis and cholelithiasis); monitor liver function and consider discontinuation or dose reduction if abnormalities occur. Correct severe fluid and electrolyte disorders, fluid overload states, and metabolic disorders prior to initiating. Measure serum triglycerides at baseline, with each dose increase, and regularly during therapy. Monitor overall energy intake, other sources of fat and glucose, drugs that may interfere with lipid and glucose metabolism. Discontinue and treat if hypersensitivity reactions occur. Monitor for signs/symptoms of infection and essential fatty acid deficiency (EFAD). Severely undernourished: avoid overfeeding. Pulmonary edema or heart failure: monitor fluid status closely. Monitor fluids, electrolytes, serum osmolarity, blood glucose, liver and kidney function, CBCs, platelets, coagulation parameters throughout treatment. Hepatic impairment. Elderly. Neonates: risk of thrombocytopenia; monitor platelets frequently. Pregnancy. Nursing mothers.

Nutrilipid Pharmacokinetics

See Literature

Nutrilipid Interactions


Vitamin K content may antagonize anticoagulants (eg, coumarin, warfarin); monitor. High lipid levels in plasma may interfere with the results of certain blood tests.

Nutrilipid Adverse Reactions

Adverse Reactions

Hyperlipidemia, hypercoagulability, thrombophlebitis, thrombocytopenia; hypersensitivity reactions, infections, refeeding syndrome, PNALD, hypertriglyceridemia, aluminum toxicity (esp. preterm infants, renal impairment); rare: fat overload syndrome.

Nutrilipid Clinical Trials

See Literature

Nutrilipid Note

Not Applicable

Nutrilipid Patient Counseling

See Literature