Migraine and headache:

Indications for: NURTEC ODT

Acute treatment of migraine with or without aura. Preventive treatment of episodic migraine.

Adult Dosage:

Allow tablet to dissolve on tongue. Acute: 75mg once as needed (max daily dose). Preventive: 75mg every other day. The safety of using more than 18 doses in a 30-day period has not been established.

Children Dosage:

Not established.

NURTEC ODT Warnings/Precautions:

Discontinue if hypersensitivity reaction occurs; treat appropriately. Severe hepatic impairment (Child-Pugh C) or ESRD (CrCl <15mL/min): avoid. Dialysis: not studied. Pregnancy. Nursing mothers.

NURTEC ODT Classification:

Calcitonin gene-related peptide (CGRP) receptor antagonist.

NURTEC ODT Interactions:

Potentiated by strong CYP3A4 inhibitors (eg, itraconazole); avoid concomitant use. May be potentiated by moderate CYP3A4 or potent P-gp inhibitors (eg, amiodarone, cyclosporine, lapatinib, quinidine, ranolazine). Avoid another dose of Nurtec ODT within 48hrs when used with moderate CYP3A4 or potent P-gp inhibitors. May be antagonized by strong or moderate CYP3A inducers (eg, rifampin); avoid concomitant use.

Adverse Reactions:

Nausea; delayed serious hypersensitivity.

Generic Drug Availability:

NO

How Supplied:

ODT tabs—8