Nuplazid

— THERAPEUTIC DISORDERS TREATED —
  • Psychosis

Nuplazid Generic Name & Formulations

General Description

Pimavanserin 10mg; tabs.

Pharmacological Class

Atypical antipsychotic.

How Supplied

Tabs, caps—30

Manufacturer

Generic Availability

NO

Nuplazid Indications

Indications

Treatment of hallucinations and delusions associated with Parkinson's disease (PD) psychosis.

Nuplazid Dosage and Administration

Adult

Caps: may be swallowed whole or opened and entire contents sprinkled over a tablespoon (15mL) of applesauce, yogurt, pudding, or a liquid nutritional supplement; consume mixture immediately without chewing. 34mg once daily ­without titration. Concomitant strong CYP3A4 inhibitors: 10mg once daily. Concomitant strong or moderate CYP3A4 inducers: avoid.

Children

Not established.

Nuplazid Contraindications

Not Applicable

Nuplazid Boxed Warnings

Boxed Warning

Increased mortality in elderly patients with dementia-related psychosis.

Nuplazid Warnings/Precautions

Warnings/Precautions

Elderly with dementia-related psychosis: increased risk of death. Not for treating patients with dementia-related psychosis unrelated to the hallucinations/delusions associated with PD psychosis. Avoid in patients with known or congenital QT prolongation, history of cardiac arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia. Severe renal impairment (CrCl <30mL/min), ESRD. Pregnancy. Nursing mothers.

Nuplazid Pharmacokinetics

See Literature

Nuplazid Interactions

Interactions

Potentiated by strong CYP3A4 inhibitors (eg, itraconazole, ketoconazole, clarithromycin, indinavir); see Adults. Antagonized by strong CYP3A4 inducers (eg, rifampin, carbamazepine, phenytoin, St. John's wort) or moderate CYP3A4 inducers (eg, modafinil, thioridazine, efavirenz, nafcillin); see Adults. Avoid concomitant drugs known to prolong QT interval including Class 1A (eg, quinidine, procainamide, disopyramide) or Class 3 antiarrhythmics (eg, amiodarone, sotalol), certain antipsychotics (eg, ziprasidone, chlorpromazine, thioridazine), and certain antibiotics (eg, gatifloxacin, moxifloxacin).

Nuplazid Adverse Reactions

Adverse Reactions

Peripheral edema, confusional state, nausea, hallucination, constipation, gait disturbance.

Nuplazid Clinical Trials

See Literature

Nuplazid Note

Not Applicable

Nuplazid Patient Counseling

See Literature

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