Nuplazid Capsules

  • Psychosis

Nuplazid Capsules Generic Name & Formulations

General Description

Pimavanserin 34mg.

Pharmacological Class

Atypical antipsychotic.

See Also

How Supplied

Tabs, caps—30


Generic Availability


Nuplazid Capsules Indications


Treatment of hallucinations and delusions associated with Parkinson's disease (PD) psychosis.

Nuplazid Capsules Dosage and Administration


Caps: may be swallowed whole or opened and entire contents sprinkled over a tablespoon (15mL) of applesauce, yogurt, pudding, or a liquid nutritional supplement; consume mixture immediately without chewing. 34mg once daily ­without titration. Concomitant strong CYP3A4 inhibitors: 10mg once daily. Concomitant strong or moderate CYP3A4 inducers: avoid.


Not established.

Nuplazid Capsules Contraindications

Not Applicable

Nuplazid Capsules Boxed Warnings

Boxed Warning

Increased mortality in elderly patients with dementia-related psychosis.

Nuplazid Capsules Warnings/Precautions


Elderly with dementia-related psychosis: increased risk of death. Not for treating patients with dementia-related psychosis unrelated to the hallucinations/delusions associated with PD psychosis. Avoid in patients with known or congenital QT prolongation, history of cardiac arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia. Severe renal impairment (CrCl <30mL/min), ESRD. Pregnancy. Nursing mothers.

Nuplazid Capsules Pharmacokinetics

See Literature

Nuplazid Capsules Interactions


Potentiated by strong CYP3A4 inhibitors (eg, itraconazole, ketoconazole, clarithromycin, indinavir); see Adults. Antagonized by strong CYP3A4 inducers (eg, rifampin, carbamazepine, phenytoin, St. John's wort) or moderate CYP3A4 inducers (eg, modafinil, thioridazine, efavirenz, nafcillin); see Adults. Avoid concomitant drugs known to prolong QT interval including Class 1A (eg, quinidine, procainamide, disopyramide) or Class 3 antiarrhythmics (eg, amiodarone, sotalol), certain antipsychotics (eg, ziprasidone, chlorpromazine, thioridazine), and certain antibiotics (eg, gatifloxacin, moxifloxacin).

Nuplazid Capsules Adverse Reactions

Adverse Reactions

Peripheral edema, confusional state, nausea, hallucination, constipation, gait disturbance.

Nuplazid Capsules Clinical Trials

See Literature

Nuplazid Capsules Note

Not Applicable

Nuplazid Capsules Patient Counseling

See Literature