Nuplazid Capsules Generic Name & Formulations
Nuplazid Capsules Indications
Treatment of hallucinations and delusions associated with Parkinson's disease (PD) psychosis.
Nuplazid Capsules Dosage and Administration
Caps: may be swallowed whole or opened and entire contents sprinkled over a tablespoon (15mL) of applesauce, yogurt, pudding, or a liquid nutritional supplement; consume mixture immediately without chewing. 34mg once daily without titration. Concomitant strong CYP3A4 inhibitors: 10mg once daily. Concomitant strong or moderate CYP3A4 inducers: avoid.
Nuplazid Capsules Contraindications
Nuplazid Capsules Boxed Warnings
Increased mortality in elderly patients with dementia-related psychosis.
Nuplazid Capsules Warnings/Precautions
Elderly with dementia-related psychosis: increased risk of death. Not for treating patients with dementia-related psychosis unrelated to the hallucinations/delusions associated with PD psychosis. Avoid in patients with known or congenital QT prolongation, history of cardiac arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia. Severe renal impairment (CrCl <30mL/min), ESRD. Pregnancy. Nursing mothers.
Nuplazid Capsules Pharmacokinetics
Nuplazid Capsules Interactions
Potentiated by strong CYP3A4 inhibitors (eg, itraconazole, ketoconazole, clarithromycin, indinavir); see Adults. Antagonized by strong CYP3A4 inducers (eg, rifampin, carbamazepine, phenytoin, St. John's wort) or moderate CYP3A4 inducers (eg, modafinil, thioridazine, efavirenz, nafcillin); see Adults. Avoid concomitant drugs known to prolong QT interval including Class 1A (eg, quinidine, procainamide, disopyramide) or Class 3 antiarrhythmics (eg, amiodarone, sotalol), certain antipsychotics (eg, ziprasidone, chlorpromazine, thioridazine), and certain antibiotics (eg, gatifloxacin, moxifloxacin).
Nuplazid Capsules Adverse Reactions
Peripheral edema, confusional state, nausea, hallucination, constipation, gait disturbance.
Nuplazid Capsules Clinical Trials
Nuplazid Capsules Note
Nuplazid Capsules Patient Counseling