Asthma/COPD:
Indications for: NUCALA
Add-on maintenance treatment of severe asthma with an eosinophilic phenotype.
Limitations of Use:
Not for relief of acute bronchospasm or status asthmaticus.
Adults and Children:
<6yrs: not established. Give by SC inj into upper arm, thigh, or abdomen. 6–11yrs (use vials or 40mg/0.4mL prefilled syringes): 40mg once every 4 weeks. ≥12yrs: 100mg once every 4 weeks.
NUCALA Warnings/Precautions:
Not for treating acute asthma symptoms or exacerbations. Opportunistic infections (eg, herpes zoster); consider vaccination if appropriate. Treat pre-existing helminth infections prior to initiation; if infection develops and unresponsive to antihelmintics, discontinue Nucala until resolves. Avoid abrupt discontinuation of any corticosteroids upon Nucala initiation; reduce gradually if appropriate. Elderly. Pregnancy. Nursing mothers.
NUCALA Classification:
Interleukin-5 antagonist.
Adverse Reactions:
Headache, inj site reactions, back pain, fatigue, oropharyngeal pain, arthralgia; infections, hypersensitivity reactions (discontinue if occur); possible antibody formation.
Generic Drug Availability:
NO
How Supplied:
Single-dose vial (100mg)—1; Single-dose autoinjector (100mg/mL)—1 (w. needle); Single-dose prefilled syringe (100mg/mL, 40mg/0.4mL)—1 (w. needle)
Miscellaneous immune disorders:
Indications for: NUCALA
Eosinophilic granulomatosis with polyangiitis (EGPA) in adults. Treatment of patients with hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause.
Adult Dosage:
Give by SC inj into upper arm, thigh, or abdomen. 300mg (as three separate 100mg inj) once every 4 weeks; inject at least 2 inches apart if at the same site.
Children Dosage:
EGPA (<18yrs): not established. HES (<12yrs): not established.
NUCALA Warnings/Precautions:
Not for treating acute asthma symptoms or exacerbations. Opportunistic infections (eg, herpes zoster); consider vaccination if appropriate. Treat pre-existing helminth infections prior to initiation; if infection develops and unresponsive to antihelmintics, discontinue Nucala until resolves. Avoid abrupt discontinuation of any corticosteroids upon Nucala initiation; reduce gradually if appropriate. Elderly. Pregnancy. Nursing mothers.
NUCALA Classification:
Interleukin-5 antagonist.
Adverse Reactions:
Headache, inj site reactions, back pain, fatigue, oropharyngeal pain, arthralgia; infections, hypersensitivity reactions (discontinue if occur); possible antibody formation.
Generic Drug Availability:
NO
How Supplied:
Single-dose vial (100mg)—1; Single-dose autoinjector (100mg/mL)—1 (w. needle); Single-dose prefilled syringe (100mg/mL, 40mg/0.4mL)—1 (w. needle)
Miscellaneous respiratory disorders:
Indications for: NUCALA
Add-on maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adults with inadequate response to nasal corticosteroids.
Adult Dosage:
Give by SC inj into upper arm, thigh, or abdomen. ≥18yrs: 100mg once every 4 weeks.
Children Dosage:
<18yrs: not established.
NUCALA Warnings/Precautions:
Not for treating acute asthma symptoms or exacerbations. Opportunistic infections (eg, herpes zoster); consider vaccination if appropriate. Treat pre-existing helminth infections prior to initiation; if infection develops and unresponsive to antihelmintics, discontinue Nucala until resolves. Avoid abrupt discontinuation of any corticosteroids upon Nucala initiation; reduce gradually if appropriate. Elderly. Pregnancy. Nursing mothers.
NUCALA Classification:
Interleukin-5 antagonist.
Adverse Reactions:
Headache, inj site reactions, back pain, fatigue, oropharyngeal pain, arthralgia; infections, hypersensitivity reactions (discontinue if occur); possible antibody formation.
Generic Drug Availability:
NO
How Supplied:
Single-dose vial (100mg)—1; Single-dose autoinjector (100mg/mL)—1 (w. needle); Single-dose prefilled syringe (100mg/mL, 40mg/0.4mL)—1 (w. needle)
