• Diabetes

Novolog Generic Name & Formulations

General Description

Insulin aspart (rDNA origin) 100 Units/mL; soln for SC inj, continuous subcutaneous insulin infusion (CSII), IV infusion; contains zinc, m-cresol.

How Supplied

Vials (10mL)—1; FlexPen (3mL prefilled syringe)—5; PenFill (3mL cartridges)—5; NovoPen Echo (inj device, uses PenFill cartridges)—1


Generic Availability


Novolog Indications



Novolog Dosage and Administration


For SC inj, CSII, or IV infusion: see full labeling. Onset 10–20mins, peak 1–3hrs, duration 3–5hrs.


<2yrs: not recommended. 2–4yrs: use SC inj only. ≥4yrs: may use SC inj or CSII: see full labeling. Onset 10–20mins, peak 1–3hrs, duration 3–5hrs.

Novolog Contraindications


During episodes of hypoglycemia.

Novolog Boxed Warnings

Not Applicable

Novolog Warnings/Precautions


Instruct patients on proper administration of insulin, check insulin label before each injection, and management of hypoglycemia. Do not reuse or share pens, cartridges between patients, even if the needle is changed (or needles and syringes when using vials). Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis. Increased risk of hyperglycemia or hypoglycemia if changes in physical activity, meal patterns, renal or hepatic function, insulin regimen, administration site; and if acute illness occurs: monitor glucose more frequently and may need to adjust dose. Monitor potassium levels in patients at risk for hypokalemia (eg, concomitant K+-lowering or K+-sensitive drugs). Discontinue if hypersensitivity reactions occur. Hyperglycemia and ketoacidosis due to insulin pump device malfunction: see full labeling. Visual impairment. Renal or hepatic impairment. Pregnancy. Nursing mothers.

Novolog Pharmacokinetics

See Literature

Novolog Interactions


Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, ACE inhibitors, ARBs, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analog, sulfonamide antibiotics. Antagonized by atypical antipsychotics, corticosteroids, isoniazid, niacin, danazol, diuretics, glucagon, thiazides, phenothiazines, sympathomimetics, somatropin, thyroid hormones, estrogens, progestogens, protease inhibitors. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. Concomitant β-blockers, clonidine, guanethidine, reserpine may blunt hypoglycemia. CSII: Do not mix with other insulins or diluent when pump is used.

Novolog Adverse Reactions

Adverse Reactions

Hypoglycemia, hypokalemia, local inj site reactions, lipodystrophy, rash, pruritus, edema, sodium retention, weight gain; hypersensitivity and allergic reactions.

Novolog Clinical Trials

See Literature

Novolog Note

Not Applicable

Novolog Patient Counseling

See Literature