Novolog Mix 70/30

  • Diabetes

Novolog Mix 70/30 Generic Name & Formulations

General Description

Insulin aspart protamine suspension 70% (rDNA origin), insulin aspart 30% (rDNA origin) 100 Units/mL; SC inj; contains zinc, m-cresol.

How Supplied

Vials (10mL)—1; FlexPen (3mL)—1


Generic Availability


Novolog Mix 70/30 Indications



Novolog Mix 70/30 Dosage and Administration


For SC inj only. Onset 10–20mins, peak 1.8–3.6hrs, duration up to 24hrs.


Not established.

Novolog Mix 70/30 Contraindications


During episodes of hypoglycemia.

Novolog Mix 70/30 Boxed Warnings

Not Applicable

Novolog Mix 70/30 Warnings/Precautions


Instruct patients on proper administration of insulin, check insulin label before each injection, and management of hypoglycemia. Do not reuse or share pens between patients, even if the needle is changed (or needles and syringes when using vials). Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis. Increased risk of hyperglycemia or hypoglycemia if changes in physical activity, meal patterns, renal or hepatic function, insulin regimen, administration site; and if acute illness occurs: monitor glucose more frequently and may need to adjust dose. Monitor potassium levels in patients at risk for hypokalemia (eg, concomitant K+-lowering or K+-sensitive drugs). Discontinue if hypersensitivity reactions occur. Hyperglycemia and ketoacidosis due to insulin pump device malfunction: see full labeling. Visual impairment. Renal or hepatic impairment. Pregnancy. Nursing mothers.

Novolog Mix 70/30 Pharmacokinetics

See Literature

Novolog Mix 70/30 Interactions


Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, ACE inhibitors, ARBs, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analog, sulfonamide antibiotics. Antagonized by atypical antipsychotics, corticosteroids, isoniazid, niacin, danazol, diuretics, glucagon, thiazides, phenothiazines, sympathomimetics, somatropin, thyroid hormones, estrogens, progestogens, protease inhibitors. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. Concomitant β-blockers, clonidine, guanethidine, reserpine may blunt hypoglycemia. Do not mix with other insulins.

Novolog Mix 70/30 Adverse Reactions

Adverse Reactions

Hypoglycemia, hypokalemia, local inj site reactions, lipodystrophy, rash, pruritus, edema, sodium retention, weight gain; hypersensitivity and allergic reactions.

Novolog Mix 70/30 Clinical Trials

See Literature

Novolog Mix 70/30 Note

Not Applicable

Novolog Mix 70/30 Patient Counseling

See Literature