Novolin N

  • Diabetes

Novolin N Generic Name & Formulations

General Description

Insulin isophane suspension (NPH) (human, rDNA origin) 100 Units/mL; susp for SC inj.

How Supplied

Vials (10mL)—1; FlexPen (3mL)—1


Generic Availability


Novolin N Indications



Novolin N Dosage and Administration

Adults and Children

Individualize. SC inj only. Rotate inj sites. Onset approx 1–2hrs, peak 4–12hrs, duration up to 24hrs.

Novolin N Contraindications


During episodes of hypoglycemia.

Novolin N Boxed Warnings

Not Applicable

Novolin N Warnings/Precautions


Instruct patients on proper administration of insulin, check insulin label before each injection, and management of hypoglycemia. Do not reuse or share pens, needles, or syringes between patients, even if the needle is changed. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis. Increased risk of hyperglycemia or hypoglycemia if changes in physical activity, meal patterns, concomitant medications, renal or hepatic function, insulin regimen, administration site, and if acute illness occurs: monitor glucose more frequently and may need to adjust dose. Monitor potassium levels in patients at risk for hypokalemia (eg, concomitant K+-lowering or K+-sensitive drugs). Discontinue if hypersensitivity reactions occur. Renal or hepatic impairment. Elderly. Pregnancy. Nursing mothers.

Novolin N Pharmacokinetics

See Literature

Novolin N Interactions


Concomitant thiazolidinediones (TZDs) may cause fluid retention and heart failure; consider dose reduction or discontinue TZDs. Potentiated by oral antidiabetic agents, ACE inhibitors, ARBs, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, pramlintide, salicylates, somatostatin analogs (eg, octreotide), sulfonamide antibiotics. Antagonized by atypical antipsychotics, corticosteroids, isoniazid, niacin, danazol, diuretics, glucagon, phenothiazines, sympathomimetics, somatropin, thyroid hormones, oral contraceptives, estrogens, progestogens, protease inhibitors. Variable effects with β-blockers, clonidine, lithium salts, alcohol, pentamidine. Concomitant β-blockers, clonidine, guanethidine, reserpine may blunt hypoglycemia.

Novolin N Adverse Reactions

Adverse Reactions

Hypoglycemia, allergic reactions, inj site reactions, lipodystrophy, weight gain, hypokalemia, peripheral edema.

Novolin N Clinical Trials

See Literature

Novolin N Note

Not Applicable

Novolin N Patient Counseling

See Literature