• Parkinsonism

Nourianz Generic Name & Formulations

General Description

Istradefylline 20mg, 40mg; tabs.

Pharmacological Class

Adenosine receptor antagonist.

How Supplied



Generic Availability


Nourianz Indications


As adjunct to levodopa/carbidopa in adults with Parkinson's disease experiencing "off" episodes.

Nourianz Dosage and Administration


20mg once daily. May increase to max 40mg once daily, if needed and tolerated. Concomitant strong CYP3A4 inhibitors: max 20mg once daily. Moderate hepatic impairment: max 20mg once daily; monitor closely. Smokers (≥20 cigarettes/day): 40mg once daily.


Not established.

Nourianz Contraindications

Not Applicable

Nourianz Boxed Warnings

Not Applicable

Nourianz Warnings/Precautions


Pre-existing dyskinesia. Avoid in major psychotic disorder. Consider dose reduction or discontinuation if hallucinations, psychotic behaviors, or urges/compulsive behaviors develop. Severe hepatic impairment: avoid. ESRD and/or requiring hemodialysis. Advise females of reproductive potential to use effective contraception during treatment. Pregnancy: not recommended. Nursing mothers.

Nourianz Pharmacokinetics

See Literature

Nourianz Interactions


Potentiated by strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clarithromycin); see Adults. Antagonized by strong CYP3A4 inducers (eg, carbamazepine, rifampin, phenytoin, St. John's wort); avoid concomitant use. Potentiates P-gp substrates (eg, digoxin); monitor. Potentiates CYP3A4 substrates (eg, atorvastatin) when concomitant Nourianz 40mg; monitor. Efficacy may be decreased by tobacco smoking; see Adults.

Nourianz Adverse Reactions

Adverse Reactions

Dyskinesia (monitor), dizziness, constipation, nausea, hallucination, insomnia; urges/compulsive behaviors.

Nourianz Clinical Trials

See Literature

Nourianz Note

Not Applicable

Nourianz Patient Counseling

See Literature