Nortriptyline Oral Solution

  • Mood disorders

Nortriptyline Oral Solution Generic Name & Formulations

General Description

Nortriptyline (as HCl) 10mg/5mL; contains alcohol 4%.

Pharmacological Class


See Also

How Supplied

Caps—30; Soln—contact supplier

Nortriptyline Oral Solution Indications



Nortriptyline Oral Solution Dosage and Administration


Initially 25mg 3–4 times daily; max 150mg/day. Elderly and adolescents: 30–50mg/day in single or divided doses.


Not recommended.

Nortriptyline Oral Solution Contraindications


During or within 14 days of MAOIs. Concomitant linezolid or IV methylene blue. Acute post-MI.

Nortriptyline Oral Solution Boxed Warnings

Boxed Warning

Suicidality and antidepressant drugs.

Nortriptyline Oral Solution Warnings/Precautions


Increased risk of suicidal thinking and behavior in children, adolescents and young adults; monitor for clinical worsening and unusual changes. Monitor for emergence of serotonin syndrome; discontinue if occurs. Mania/hypomania. Bipolar disorder. Psychosis. ECT. Cardiovascular disease. Avoid in Brugada syndrome. Angle-closure glaucoma. Urinary retention. Epilepsy. Hyperthyroidism. Diabetes. Liver disorders. Monitor plasma levels if dose >100mg/day. Elderly. Pregnancy. Nursing mothers.

Nortriptyline Oral Solution Pharmacokinetics

See Literature

Nortriptyline Oral Solution Interactions


See Contraindications. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Potentiates alcohol, sympathomimetics. CNS stimulation with reserpine. Potentiated by CYP2D6 inhibitors; monitor plasma levels with quinidine, cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, propafenone, flecainide). Antagonized by barbiturates, carbamazepine. Paralytic ileus, hyperpyrexia with anticholinergics. Blocks guanethidine.

Nortriptyline Oral Solution Adverse Reactions

Adverse Reactions

Drowsiness, anticholinergic effects, CNS overstimulation, arrhythmias, extrapyramidal symptoms, hypo- or hypertension, nausea, fatigue, rash, headache, changes in blood sugar, photosensitivity, edema, blood dyscrasias, jaundice.

Nortriptyline Oral Solution Clinical Trials

See Literature

Nortriptyline Oral Solution Note

Not Applicable

Nortriptyline Oral Solution Patient Counseling

See Literature