• Hypotension

Northera Generic Name & Formulations

General Description

Droxidopa 100mg, 200mg, 300mg+; capsules; (+) contains tartrazine.

Pharmacological Class

Norepinephrine prodrug.

How Supplied



Generic Availability


Northera Indications


Symptomatic neurogenic orthostatic hypotension (NOH) caused by primary autonomic failure (Parkinson's disease, multiple system atrophy, and pure autonomic failure), dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy.

Northera Dosage and Administration


Swallow whole. Take with or without food. Initially 100mg three times daily in the morning, midday, and late afternoon (≥3hrs prior to bedtime). Titrate in increments of 100mg three times daily every 24–48hrs; max 600mg three times daily.


Not established.

Northera Contraindications

Not Applicable

Northera Boxed Warnings

Boxed Warning

Supine hypertension.

Northera Warnings/Precautions


May cause or exacerbate supine hypertension. Monitor BP (supine and head-elevated sleeping positions) prior to initiating and after increasing the dose; reduce dose or discontinue if supine hypertension persists. Monitor for symptoms of neuroleptic malignant syndrome; observe carefully during dose changes or when concomitant levodopa is reduced abruptly or discontinued, especially if receiving neuroleptics. May exacerbate ischemic heart disease, arrhythmias, CHF. Discontinue if hypersensitivity reactions occur. Allergic reactions (tartrazine). Reevaluate periodically. Severe renal impairment (GFR <30mL/min): limited data. Pregnancy. Nursing mothers: not recommended.

Northera Pharmacokinetics

See Literature

Northera Interactions


Concomitant drugs that increase BP (eg, norepinephrine, ephedrine, midodrine, and triptans); increased risk of supine hypertension. Concomitant dopa-decarboxylase inhibitors: may need to adjust droxidopa dose. Avoid concomitant non-selective MAOIs or linezolid.

Northera Adverse Reactions

Adverse Reactions

Headache, dizziness, nausea, hypertension, falls, UTI, syncope; hyperpyrexia, confusion.

Northera Clinical Trials

See Literature

Northera Note

Not Applicable

Northera Patient Counseling

See Literature