Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Norpramin Generic Name & Formulations
Legal Class
Rx
General Description
Desipramine HCl 10mg, 25mg, 50mg, 75mg, 100mg, 150mg; tabs.
Pharmacological Class
Tricyclic.
How Supplied
Tabs 10mg, 25mg, 50mg, 75mg, 100mg—100; 150mg—50
Manufacturer
Norpramin Indications
Indications
Depression.
Norpramin Dosage and Administration
Adult
100–200mg daily in single or divided doses; max 300mg/day. Hospitalize initially if dose is 300mg/day; monitor ECG. Elderly and adolescents: 25–100mg daily in single or divided doses; max 150mg/day.
Children
Not recommended.
Norpramin Contraindications
Contraindications
During or within 14 days of MAOIs. Concomitant linezolid or IV methylene blue. Acute post-MI.
Norpramin Boxed Warnings
Boxed Warning
Suicidality and antidepressant drugs.
Norpramin Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thinking and behavior in children, adolescents and young adults; monitor for clinical worsening and unusual changes. Monitor for emergence of serotonin syndrome; discontinue if occurs. Screen for bipolar disorder. Psychosis. Mania/hypomania. Cardiovascular disease. Family history of sudden death, cardiac dysrhythmias or conduction disturbances. Urinary retention. Angle-closure glaucoma. Epilepsy. ECT. Hyperthyroidism. Diabetes. Hepatic or renal dysfunction. Perform leukocyte and differential counts if fever and sore throat develop; discontinue if neutrophil depression occurs. Discontinue before surgery. Write ℞ for smallest practical amount. Elderly. Pregnancy. Nursing mothers.
Norpramin Pharmacokinetics
See Literature
Norpramin Interactions
Interactions
See Contraindications. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Potentiates alcohol, anticholinergics, sympathomimetics, benzodiazepines, other CNS depressants. Potentiated by CYP2D6 inhibitors; monitor plasma levels with cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, quinidine, propafenone, flecainide). Antagonized by barbiturates, carbamazepine. Paralytic ileus, hyperpyrexia with anticholinergics. Blocks guanethidine. Possible cardiotoxicity with concomitant thyroid medications.
Norpramin Adverse Reactions
Adverse Reactions
Drowsiness, anticholinergic effects, arrhythmias, extrapyramidal symptoms, hypo- or hypertension, nausea, fatigue, rash, hyperhidrosis, headache, changes in blood sugar, photosensitivity, edema, blood dyscrasias, jaundice.
Norpramin Clinical Trials
See Literature
Norpramin Note
Not Applicable
Norpramin Patient Counseling
See Literature
