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Nifedipine Ext-rel Generic Name & Formulations
Legal Class
Rx
General Description
Nifedipine 30mg, 60mg, 90mg; ext-rel tabs.
Pharmacological Class
Calcium channel blocker (CCB) (dihydropyridine).
How Supplied
Contact supplier
Manufacturer
Nifedipine Ext-rel Indications
Indications
Hypertension.
Nifedipine Ext-rel Dosage and Administration
Adult
Swallow whole on empty stomach. Initially 30mg once daily. Usual maintenance: 30–60mg once daily. Titrate over 7–14 days; max 90mg/day.
Children
Not established.
Nifedipine Ext-rel Contraindications
Not Applicable
Nifedipine Ext-rel Boxed Warnings
Not Applicable
Nifedipine Ext-rel Warnings/Precautions
Warnings/Precautions
Aortic stenosis. Angina. Severe obstructive coronary artery disease. Heart failure. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Nifedipine Ext-rel Pharmacokinetics
See Literature
Nifedipine Ext-rel Interactions
Interactions
Potentiates antihypertensives, digoxin, tacrolimus. Angina and heart failure possible with β-blockers. Potentiated by cimetidine, doxazosin, ketoconazole, valproic acid, grapefruit juice, other CYP3A4 inhibitors. Antagonized by rifampin, phenytoin, carbamazepine, St. John's wort, other CYP3A4 inducers. Monitor oral anticoagulants, quinidine. Hypotension possible with fentanyl.
Nifedipine Ext-rel Adverse Reactions
Adverse Reactions
Peripheral edema, headache, flushing, dizziness, fatigue, constipation, muscle cramps, rash; exacerbation of angina, heart failure (rare).
Nifedipine Ext-rel Clinical Trials
See Literature
Nifedipine Ext-rel Note
Notes
Formerly known under the brand name Adalat CC.
Nifedipine Ext-rel Patient Counseling
See Literature
