Indications for: Nifedipine Ext-Rel
Swallow whole on empty stomach. Initially 30mg once daily. Usual maintenance: 30–60mg once daily. Titrate over 7–14 days; max 90mg/day.
Nifedipine Ext-Rel Warnings/Precautions:
Aortic stenosis. Angina. Severe obstructive coronary artery disease. Heart failure. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Nifedipine Ext-Rel Classification:
Calcium channel blocker (CCB) (dihydropyridine).
Nifedipine Ext-Rel Interactions:
Potentiates antihypertensives, digoxin, tacrolimus. Angina and heart failure possible with β-blockers. Potentiated by cimetidine, doxazosin, ketoconazole, valproic acid, grapefruit juice, other CYP3A4 inhibitors. Antagonized by rifampin, phenytoin, carbamazepine, St. John's wort, other CYP3A4 inducers. Monitor oral anticoagulants, quinidine. Hypotension possible with fentanyl.
Peripheral edema, headache, flushing, dizziness, fatigue, constipation, muscle cramps, rash; exacerbation of angina, heart failure (rare).
Formerly known under the brand name Adalat CC.