Nifedipine Ext-rel Generic Name & Formulations
Nifedipine 30mg, 60mg, 90mg; ext-rel tabs.
Calcium channel blocker (CCB) (dihydropyridine).
Nifedipine Ext-rel Indications
Nifedipine Ext-rel Dosage and Administration
Swallow whole on empty stomach. Initially 30mg once daily. Usual maintenance: 30–60mg once daily. Titrate over 7–14 days; max 90mg/day.
Nifedipine Ext-rel Contraindications
Nifedipine Ext-rel Boxed Warnings
Nifedipine Ext-rel Warnings/Precautions
Aortic stenosis. Angina. Severe obstructive coronary artery disease. Heart failure. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Nifedipine Ext-rel Pharmacokinetics
Nifedipine Ext-rel Interactions
Potentiates antihypertensives, digoxin, tacrolimus. Angina and heart failure possible with β-blockers. Potentiated by cimetidine, doxazosin, ketoconazole, valproic acid, grapefruit juice, other CYP3A4 inhibitors. Antagonized by rifampin, phenytoin, carbamazepine, St. John's wort, other CYP3A4 inducers. Monitor oral anticoagulants, quinidine. Hypotension possible with fentanyl.
Nifedipine Ext-rel Adverse Reactions
Peripheral edema, headache, flushing, dizziness, fatigue, constipation, muscle cramps, rash; exacerbation of angina, heart failure (rare).
Nifedipine Ext-rel Clinical Trials
Nifedipine Ext-rel Note
Formerly known under the brand name Adalat CC.
Nifedipine Ext-rel Patient Counseling