Nicotrol Ns Generic Name & Formulations
Nicotine 0.5mg/spray; aqueous nasal spray.
Inhaler 168 cartridges—1 (w. mouthpieces and case); Nasal Spray 10mL (200 sprays)—4 (w. metered spray pump)
Nicotrol Ns Indications
Adjunct in smoking cessation therapy.
Nicotrol Ns Dosage and Administration
Do not sniff, swallow, or inhale. Individualize. Usually 1–2 doses/hour; max 5 doses/hour, 40 doses/day for up to 3 months; may discontinue abruptly or taper.
Nicotrol Ns Contraindications
Concurrent smoking or other nicotine products.
Nicotrol Ns Boxed Warnings
Nicotrol Ns Warnings/Precautions
Sustained use (>6 months): not recommended. Avoid immediately post-MI, in arrhythmias, or severe or worsening angina pectoris. Hypertension. Vasospastic or coronary heart disease. Bronchospastic disease. Severe reactive airway disease: not recommended. Hepatic or moderate/severe renal impairment. Hyperthyroidism. Pheochromocytoma. Diabetes. Esophagitis. Active gastric or peptic ulcers. Elderly. Low doses may be toxic to children and pets. Nasal Spray: nasal mucosal disorders. Pregnancy, labor & delivery: not recommended (attempt nondrug treatment first). Nursing mothers.
Nicotrol Ns Pharmacokinetics
Nicotrol Ns Interactions
Nasal Spray antagonized by nasal vasoconstrictors (eg, xylometazoline). Smoking cessation potentiates theophylline, insulin, β-blockers, pentazocine, oxazepam, tricyclic antidepressants (eg, imipramine), caffeine, acetaminophen, adrenergic antagonists (eg, prazosin, labetalol), others. Smoking cessation antagonizes adrenergic agonists (eg, isoproterenol, phenylephrine), others.
Nicotrol Ns Adverse Reactions
Local irritation, nausea, diarrhea, hiccup, dyspepsia, headache, dizziness, palpitations, hypertension.
Nicotrol Ns Clinical Trials
Nicotrol Ns Note
Nicotrol Ns Patient Counseling