Nexviazyme

Risk of severe hypersensitivity reactions (including anaphylaxis); discontinue immediately if occurs. Have appropriate medical support and resuscitative equipment readily available. Monitor for severe infusion-associated reactions (IARs); consider immediate discontinuation if occurs. Withhold temporarily or slow the infusion rate if mild or moderate hypersensitivity reactions or moderate IARs occur. Increased risk of severe complications from IARs in those with advanced Pompe disease. Fluid volume overload, acute underlying respiratory illness, or compromised cardiac/respiratory function (with fluid restriction): risk of acute cardiorespiratory failure; monitor vitals frequently. Pregnancy. Nursing mothers.