• Hyperlipoproteinemias

Nexlizet Generic Name & Formulations

General Description

Bempedoic acid 180mg, ezetimibe 10mg; tabs.

Pharmacological Class

Adenosine triphosphate-citrate lyase (ACL) inhibitor + cholesterol absorption inhibitor.

How Supplied

Tabs—30, 90

Generic Availability


Nexlizet Indications


An adjunct to diet and maximally tolerated statin therapy, in adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.

Limitations of Use

The effect on cardiovascular morbidity and mortality has not been determined.

Nexlizet Dosage and Administration


Swallow whole. 180mg/10mg once daily. After initiation, assess lipid levels within 8–12 weeks. Concomitant bile acid sequestrants: give Nexlizet either ≥2hrs before or ≥4hrs after.


Not established.

Nexlizet Contraindications

Not Applicable

Nexlizet Boxed Warnings

Not Applicable

Nexlizet Warnings/Precautions


Hyperuricemia. Assess serum uric acid as clinically indicated. History of gout. Increased risk for tendon rupture/injury (esp. >60yrs, in those taking corticosteroid or fluoroquinolone drugs, renal failure, previous tendon disorders); consider discontinuing if joint pain, swelling, or inflammation develop. History of tendon disorders/rupture: consider alternative therapy. Elderly. Moderate or severe hepatic (Child-Pugh B or C): not recommended. Severe renal impairment (eGFR <30mL/min/1.73 m2). ESRD on dialysis. Pregnancy, nursing mothers: not recommended.

Nexlizet Pharmacokinetics

See Literature

Nexlizet Interactions


Avoid concomitant simvastatin >20mg or pravastatin >40mg. Concomitant cyclosporine increases ezetimibe and cyclosporine levels; monitor. Concomitant use with fibrates (except fenofibrate): not recommended. Concomitant use with fenofibrate: consider alternative therapy if cholelithiasis is suspected. Antagonized by cholestyramine (see Adult dose).

Nexlizet Adverse Reactions

Adverse Reactions

Upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, elevated liver enzymes, diarrhea, arthralgia, sinusitis, fatigue, influenza; BPH, atrial fibrillation, hypersensitivity reactions (ezetimibe).

Nexlizet Clinical Trials

See Literature

Nexlizet Note

Not Applicable

Nexlizet Patient Counseling

See Literature