• Hyperlipoproteinemias

Nexletol Generic Name & Formulations

General Description

Bempedoic acid 180mg; tabs.

Pharmacological Class

Adenosine triphosphate-citrate lyase (ACL) inhibitor.

How Supplied

Tabs—30, 90

Generic Availability


Nexletol Indications


An adjunct to diet and maximally tolerated statin therapy, in patients with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.

Limitations of Use

The effect of Nexletol on cardiovascular morbidity and mortality has not been determined.

Nexletol Dosage and Administration


180mg once daily.


Not established.

Nexletol Contraindications

Not Applicable

Nexletol Boxed Warnings

Not Applicable

Nexletol Warnings/Precautions


Hyperuricemia. Assess serum uric acid as clinically indicated. History of gout. Increased risk for tendon rupture/injury (esp. >60yrs, renal failure); discontinue immediately if occurs; consider discontinuing if joint pain, swelling, or inflammation develop. History of tendon disorders/rupture: consider alternative therapy. Assess lipid levels within 8–12 weeks after initiation. Elderly. Severe hepatic (Child-Pugh C) or renal impairment (eGFR <30mL/min/1.73 m2). ESRD on dialysis. Pregnancy: discontinue if occurs. Nursing mothers: not recommended.

Nexletol Pharmacokinetics

See Literature

Nexletol Interactions


Avoid concomitant simvastatin >20mg or pravastatin >40mg. Increased risk for tendon rupture with corticosteroid or fluoroquinolone drugs.

Nexletol Adverse Reactions

Adverse Reactions

Upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, elevated liver enzymes; gout, BPH.

Nexletol Clinical Trials

See Literature

Nexletol Note

Not Applicable

Nexletol Patient Counseling

See Literature