Nexium 24hr

  • Hyperacidity, GERD, and ulcers

Nexium 24hr Generic Name & Formulations

General Description

Esomeprazole 20mg (equivalent to 22.3mg esomeprazole magnesium trihydrate); delayed-release caps; contains gelatin.

Pharmacological Class

Proton pump inhibitor.

How Supplied

Caps—14, 28, 42


Nexium 24hr Indications


Frequent heartburn (≥2 days/week). Not intended for immediate relief of heartburn (may take 1–4 days for full effect).

Nexium 24hr Dosage and Administration


Swallow whole. Take before eating in the AM. ≥18yrs: 20mg once daily for 14 days; may repeat 14-day course every 4 months.


<18yrs: not recommended.

Nexium 24hr Contraindications


Trouble or pain swallowing food. Vomiting with blood. Bloody or black stools. Chest or shoulder pain with shortness of breath; sweating; pain spreading to arms, neck, or shoulders; or lightheadedness. Frequent chest pain.

Nexium 24hr Boxed Warnings

Not Applicable

Nexium 24hr Warnings/Precautions


Heartburn >3 months. Frequent wheezing. Unexplained weight loss. Nausea/vomiting. Stomach pain. Discontinue and reevaluate if condition continues or worsens after 14 days, require >1 course of treatment every 4 months; diarrhea, rash, or joint pain develops. Pregnancy. Nursing mothers.

Nexium 24hr Pharmacokinetics

See Literature

Nexium 24hr Interactions


May affect or be affected by blood-thinning agents (eg, warfarin, clopidogrel, cilostazol), antifungals, digoxin, diazepam, tacrolimus, mycophenolate mofetil, antiretrovirals, methotrexate.

Nexium 24hr Adverse Reactions

Adverse Reactions

Diarrhea, rash, joint pain; allergic or severe skin reactions (skin reddening, blisters).

Nexium 24hr Clinical Trials

See Literature

Nexium 24hr Note

Not Applicable

Nexium 24hr Patient Counseling

See Literature