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Nesina Generic Name & Formulations
Legal Class
Rx
General Description
Alogliptin 6.25mg, 12.5mg, 25mg; tabs.
Pharmacological Class
Dipeptidyl peptidase-4 (DPP-4) inhibitor.
How Supplied
Tabs 6.25mg—30, 90; 12.5mg, 25mg—30, 90, 500
Manufacturer
Generic Availability
NO
Nesina Indications
Indications
Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Limitations of Use
Not for treatment of type 1 diabetes.
Nesina Dosage and Administration
Adult
25mg once daily. Renal impairment: moderate (CrCl ≥30–<60mL/min): 12.5mg once daily; severe (CrCl ≥15–<30mL/min) or ESRD (CrCl <15mL/min or need hemodialysis): 6.25mg once daily.
Children
Not established.
Nesina Contraindications
Not Applicable
Nesina Boxed Warnings
Not Applicable
Nesina Warnings/Precautions
Warnings/Precautions
Assess renal function prior to therapy and periodically thereafter. Monitor for signs/symptoms of pancreatitis, serious hypersensitivity reactions, or severe joint pain; discontinue if suspected or occurs. Consider risks/benefits in patients with known risk factors for heart failure; monitor for signs/symptoms; evaluate and consider discontinuing if develops. History of angioedema to other DPP-4 inhibitors. Hepatic impairment. Obtain LFTs before starting therapy; interrupt and evaluate if liver enzymes elevated or abnormal tests persist; do not restart if liver injury is confirmed and no other etiology can be found. Pregnancy (Cat.B). Nursing mothers.
Nesina Pharmacokinetics
See Literature
Nesina Interactions
Interactions
May need lower dose of concomitant sulfonylurea or insulin to reduce risk of hypoglycemia.
Nesina Adverse Reactions
Adverse Reactions
Nasopharyngitis, headache, upper respiratory tract infection; pancreatitis, heart failure, hypersensitivity reactions (eg, anaphylaxis, angioedema, Stevens-Johnson syndrome), hepatic failure (may be fatal), severe and disabling arthralgia, bullous pemphigoid.
Nesina Clinical Trials
See Literature
Nesina Note
Not Applicable
Nesina Patient Counseling
See Literature
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