• Anesthetics

Nesacaine Generic Name & Formulations

General Description

Chloroprocaine HCl 10mg/mL, 20mg/mL; soln for inj; contains methylparaben.

Pharmacological Class

Local anesthetic.

See Also

How Supplied

Nesacaine: Multi-dose vial (30mL)—25; Nesacaine-MPF: Single-dose vial (20mL)—25


Nesacaine Indications


Production of local anesthesia by infiltration and peripheral nerve block.

Nesacaine Dosage and Administration


Epidural anesthesia: administer test dose first; monitor for CNS or cardiovascular toxicity. See full labeling for dosing based on procedure. Individualize. Max single recommended dose: 11mg/kg, not to exceed max total dose of 800mg. Debilitated, elderly, acutely ill (cardiac and/or liver disease): reduce dose.


<3yrs: see full labeling. Individualize based on age and weight. ≥3yrs: max 11mg/kg.

Nesacaine Contraindications

Not Applicable

Nesacaine Boxed Warnings

Not Applicable

Nesacaine Warnings/Precautions


Not for subarachnoid administration. Lumbar and caudal epidural anesthesia: caution with existing neurological disease, spinal deformities, septicemia, severe hypertension. To be administered under the supervision of experienced clinicians. Have intubation, artificial respiration, oxygen therapy and reversal agents available. Risk of methemoglobinemia (esp. in G6PD deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants <6 months of age, concurrent exposure to oxidizing agents or metabolites); monitor. Hypotension. Heart block. Monitor cardiovascular and respiratory vital signs. Impaired cardiovascular function. Hepatic impairment. Retrobulbar block. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Nesacaine Pharmacokinetics

See Literature

Nesacaine Interactions


Concomitant sulfonamides: not recommended. Concurrent vasopressor and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents. Increased risk of methemoglobinemia when concurrently exposed to nitrates/nitrites, local anesthetics, antineoplastic agents, antibiotics, antimalarials, anticonvulsants, others.

Nesacaine Adverse Reactions

Adverse Reactions

CNS effects (eg, excitation, depression, restlessness, anxiety, dizziness, tremors), cardiovascular effects (eg, myocardium depression, decreased cardiac output, heart block, hypotension, bradycardia, ventricular arrhythmias, cardiac arrest), allergic-type reactions, neurologic effects (eg, spinal block, urinary retention, paresthesia, weakness, headache, paralysis of lower extremities).

Nesacaine Clinical Trials

See Literature

Nesacaine Note

Not Applicable

Nesacaine Patient Counseling

See Literature