• Fungal infections

Nebupent Generic Name & Formulations

General Description

Pentamidine isethionate 300mg/vial; lyophilized pwd for inhalation after reconstitution. To be used with the Respirgard II nebulizer.

Pharmacological Class


How Supplied

Single-dose vial—1


Nebupent Indications


For prevention of Pneumocystis jiroveci pneumonia (PJP) in high-risk, HIV-infected patients defined by one or both of the following criteria: 1) a history of one or more episodes of PJP; 2) a peripheral CD4+ lymphocyte count ≤200/mm3.

Nebupent Dosage and Administration


>16yrs: 300mg once every 4 weeks administered via the Respirgard II nebulizer. Dose should be delivered until nebulizer chamber is empty (approx. 30–45 minutes).


≤16yrs: not recommended.

Nebupent Contraindications

Not Applicable

Nebupent Boxed Warnings

Not Applicable

Nebupent Warnings/Precautions


Exclude the presence of PJP before starting prophylaxis therapy. History of smoking or asthma. May induce bronchospasm/cough; administer inhaled bronchodilator prior to giving NebuPent dose; do not use Respirgard II nebulizer to administer a bronchodilator. Pregnancy (Cat. C). Nursing mothers: not recommended.

Nebupent Pharmacokinetics

See Literature

Nebupent Interactions


Do not mix with other drugs. Additive effects with concomitant other nephrotoxic drugs (eg, aminoglycosides, amphotericin B, cisplatin, foscarnet, vancomycin); monitor closely or avoid if possible.

Nebupent Adverse Reactions

Adverse Reactions

Night sweats, GI upset, anemia, bronchitis, herpes, herpes zoster, flu, oral Candida, pharyngitis, sinusitis, upper respiratory tract infections, headache, chest pain, cough, wheezing, bad taste; monitor closely for serious adverse reactions: hypotension, hypoglycemia, hyperglycemia, hypocalcemia, thrombocytopenia, leukopenia, hepatic/renal dysfunction, ventricular tachycardia, pancreatitis (discontinue if occurs), Stevens-Johnson syndrome, hyperkalemia, abnormal ST segment; rare: extrapulmonary pneumocystosis.

Nebupent Clinical Trials

See Literature

Nebupent Note

Not Applicable

Nebupent Patient Counseling

See Literature