Seizure disorders:

Indications for NAYZILAM:

Acute treatment of intermittent, stereotypic episodes of frequent seizure activity (eg, seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in those with epilepsy.

Adult:

Give as single spray into one nostril; if no response after 10mins, may give additional spray into opposite nostril; max 2 sprays/episode. Max treatment: one episode every 3 days or 5 episodes/month.

Children:

<12yrs: not established.

Contraindications:

Acute narrow-angle glaucoma.

Boxed Warning:

Risks from concomitant use with opioids.

Warnings/Precautions:

Increased risk of drug-related mortality from concomitant use with opioids. Decreased pulmonary reserve. COPD. Monitor for the emergence or worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood or behavior. Open-angle glaucoma. Impaired cognitive function. Obesity. CHF. Avoid abrupt cessation. Drug or alcohol abuse. Hepatic or moderate to severe renal impairment. Elderly. Debilitated. Labor & delivery. Neonatal withdrawal and floppy infant syndrome. Pregnancy. Nursing mothers.

Pharmacologic Class:

Benzodiazepine.

Interactions:

Increased risk of profound sedation, respiratory depression, coma, and death with opioids or other CNS depressants (eg, other benzodiazepines, sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, alcohol); reserve concomitant use in those for whom alternative options are inadequate; limit dosages/durations to minimum required; monitor. Avoid concomitant with moderate/strong CYP3A4 inhibitors (eg, erythromycin, diltiazem, verapamil, ketoconazole, itraconazole, clarithromycin). Caution with concomitant mild CYP3A inhibitors.

Adverse Reactions:

Somnolence, headache, nasal discomfort, throat irritation, rhinorrhea; severe cardiorespiratory reactions, agitation, involuntary movements (including tonic/clonic movements and muscle tremor), hyperactivity, combativeness.

Generic Availability:

NO

How Supplied:

Single-dose nasal spray—2 units

Pricing for NAYZILAM

5mg nasal spray (Qty: 2)
Appx. price $571
GoodRx