• Diabetes

Nateglinide Generic Name & Formulations

General Description

Nateglinide 60mg, 120mg; tabs.

Pharmacological Class


How Supplied

Contact supplier

Nateglinide Indications


Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Limitations of Use

Not for treatment of type 1 diabetes or diabetic ketoacidosis.

Nateglinide Dosage and Administration


Take 1–30mins before meals; skip dose if meal is skipped. 120mg 3 times daily. If near glycemic goal, initially 60mg 3 times daily.


Not established.

Nateglinide Contraindications

Not Applicable

Nateglinide Boxed Warnings

Not Applicable

Nateglinide Warnings/Precautions


Increased risk of hypoglycemia with changes in physical activity, meal patterns, renal or hepatic impairment: monitor glucose more frequently and may need to adjust dose. Reduced symptomatic awareness of hypoglycemia in longstanding diabetes, diabetic nerve disease, or recurrent hypoglycemia. Moderate-to-severe hepatic impairment. Pregnancy (Cat.C). Nursing mothers: not recommended.

Nateglinide Pharmacokinetics

See Literature

Nateglinide Interactions


Increased hypoglycemia with concomitant other antidiabetic agents, NSAIDs, salicylates, MAOIs, non-selective β-blockers, anabolic hormones, guanethidine, and CYP2C9 inhibitors (eg, amiodarone, fluconazole, voriconazole, sulfinpyrazone), alcohol; may need dose reduction and monitor. May be antagonized by thiazides, corticosteroids, thyroid products, sympathomimetics, somatropin, somatostatin analogs (eg, lanreotide, octreotide), and CYP inducers (eg, rifampin, phenytoin, St John's Wort); may need dose increase and monitor. β-blockers, clonidine, guanethidine, reserpine may mask hypoglycemia.

Nateglinide Adverse Reactions

Adverse Reactions

Upper RTI, back pain, flu symptoms, dizziness, arthropathy, diarrhea; hypoglycemia, weight gain.

Nateglinide Clinical Trials

See Literature

Nateglinide Note


Formerly known under the brand name Starlix.

Nateglinide Patient Counseling

See Literature