• Mood disorders

Nardil Generic Name & Formulations

General Description

Phenelzine sulfate 15mg; tabs.

Pharmacological Class


How Supplied



Generic Availability


Nardil Indications


Refractory depression.

Nardil Dosage and Administration


Initially 15mg three times daily. Increase if needed to max 90mg daily. Reduce dose as condition improves.


<16 yrs: not recommended.

Nardil Contraindications


See Interactions. Pheochromocytoma. Cardiovascular, cerebrovascular, or liver disease. Hypertension. Chronic headache. To avoid potentially severe or fatal interactions, allow sufficient drug-free interval (see full labeling) between phenelzine and: sympathomimetics (eg, amphetamines, pseudoephedrine), tricyclic antidepressants (eg, amitriptyline), maprotiline, mirtazapine, SSRIs or other neurotransmitter reuptake inhibitors (eg, fluoxetine), CNS depressants (eg, alcohol, barbiturates, narcotics), antihistamines, antihypertensives (eg, guanethidine), anesthetics, bupropion, buspirone, carbamazepine, cyclobenzaprine, dibenzazepines, diuretics, dextromethorphan, dopamine, other MAOIs (eg, tranylcypromine, selegiline, furazolidone, isocarboxazid), levodopa, methyldopa, methylphenidate, tryptophan, phenylalanine, tryptophan-, dopamine-, tyrosine-, or tyramine-containing foods, excess caffeine or chocolate. Meperidine within three weeks of phenelzine.

Nardil Boxed Warnings

Boxed Warning

Suicidality and antidepressant drugs.

Nardil Warnings/Precautions


Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor all patients for clinical worsening or unusual behavioral changes. Screen for risk of bipolar disorder prior to initiation. Mania/hypomania. Psychosis. Epilepsy. Hyperthyroidism. Surgery. Discontinue if palpitations or headache occurs and 48 hrs before to 24 hrs after myelography. Avoid abrupt cessation. Hypotension. Monitor blood pressure and observe patient frequently. May mask anginal pain or aggravate anxiety or agitation. Elderly. Debilitated. Pregnancy. Nursing mothers.

Nardil Pharmacokinetics

See Literature

Nardil Interactions


See Contraindications. Hypertensive crises with sympathomimetics, levodopa, and high-tyramine foods (including cheese, salami, chocolate, wine, beer, pickled herring, chicken livers, yeast extract, yogurt, broad beans, others). Caution with antidiabetic agents, antiparkinson agents, disulfiram. Potentiates CNS depressants, antihypertensives. Psychosis with dextromethorphan. Circulatory collapse, coma, death with meperidine. Do not start within 5 wks of fluoxetine, or 2 wks of sertraline, paroxetine, bupropion, citalopram, or 1 wk of venlafaxine discontinuance.

Nardil Adverse Reactions

Adverse Reactions

Orthostatic hypotension, headache, CNS overstimulation, jaundice, seizures, changes in blood sugar, anticholinergic effects, GI disorders, rash, weight gain, sexual disturbances.

Nardil Clinical Trials

See Literature

Nardil Note

Not Applicable

Nardil Patient Counseling

See Literature