Narcan Nasal Spray

  • Poisoning/overdose

Narcan Nasal Spray Generic Name & Formulations

General Description

Naloxone HCl 4mg; per spray; contains benzalkonium chloride.

Pharmacological Class

Opioid antagonist.

How Supplied

Single-dose nasal spray—2

Generic Availability


Narcan Nasal Spray Indications


Reversal of known or suspected opioid overdose, including respiratory and/or CNS depression.

Narcan Nasal Spray Dosage and Administration

Adults and Children

Give as single spray intranasally into one nostril. May give additional doses (using a new nasal spray) every 2–3mins in alternate nostrils if unresponsive or relapses into respiratory depression. Seek immediate emergency medical assistance after the first dose.

Narcan Nasal Spray Contraindications

Not Applicable

Narcan Nasal Spray Boxed Warnings

Not Applicable

Narcan Nasal Spray Warnings/Precautions


Not a substitute for emergency medical care. Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Elderly. Pregnancy; monitor for neonatal withdrawal symptoms. Nursing mothers.

Narcan Nasal Spray Pharmacokinetics

See Literature

Narcan Nasal Spray Interactions


Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.

Narcan Nasal Spray Adverse Reactions

Adverse Reactions

Increased BP, musculoskeletal pain, headache, nasal effects (eg, dryness, edema, congestion, inflammation); opioid withdrawal.

Narcan Nasal Spray Clinical Trials

See Literature

Narcan Nasal Spray Note

Not Applicable

Narcan Nasal Spray Patient Counseling

See Literature