Narcan Nasal Spray Generic Name & Formulations
Naloxone HCl 4mg; per spray; contains benzalkonium chloride.
Single-dose nasal spray—2
Narcan Nasal Spray Indications
Reversal of known or suspected opioid overdose, including respiratory and/or CNS depression.
Narcan Nasal Spray Dosage and Administration
Adults and Children
Give as single spray intranasally into one nostril. May give additional doses (using a new nasal spray) every 2–3mins in alternate nostrils if unresponsive or relapses into respiratory depression. Seek immediate emergency medical assistance after the first dose.
Narcan Nasal Spray Contraindications
Narcan Nasal Spray Boxed Warnings
Narcan Nasal Spray Warnings/Precautions
Not a substitute for emergency medical care. Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Elderly. Pregnancy; monitor for neonatal withdrawal symptoms. Nursing mothers.
Narcan Nasal Spray Pharmacokinetics
Narcan Nasal Spray Interactions
Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.
Narcan Nasal Spray Adverse Reactions
Increased BP, musculoskeletal pain, headache, nasal effects (eg, dryness, edema, congestion, inflammation); opioid withdrawal.
Narcan Nasal Spray Clinical Trials
Narcan Nasal Spray Note
Narcan Nasal Spray Patient Counseling