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Narcan Nasal Spray Generic Name & Formulations
Legal Class
Rx
General Description
Naloxone HCl 4mg; per spray; contains benzalkonium chloride.
Pharmacological Class
Opioid antagonist.
How Supplied
Single-dose nasal spray—2
Manufacturer
Generic Availability
NO
Narcan Nasal Spray Indications
Indications
Reversal of known or suspected opioid overdose, including respiratory and/or CNS depression.
Narcan Nasal Spray Dosage and Administration
Adults and Children
Give as single spray intranasally into one nostril. May give additional doses (using a new nasal spray) every 2–3mins in alternate nostrils if unresponsive or relapses into respiratory depression. Seek immediate emergency medical assistance after the first dose.
Narcan Nasal Spray Contraindications
Not Applicable
Narcan Nasal Spray Boxed Warnings
Not Applicable
Narcan Nasal Spray Warnings/Precautions
Warnings/Precautions
Not a substitute for emergency medical care. Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Elderly. Pregnancy; monitor for neonatal withdrawal symptoms. Nursing mothers.
Narcan Nasal Spray Pharmacokinetics
See Literature
Narcan Nasal Spray Interactions
Interactions
Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.
Narcan Nasal Spray Adverse Reactions
Adverse Reactions
Increased BP, musculoskeletal pain, headache, nasal effects (eg, dryness, edema, congestion, inflammation); opioid withdrawal.
Narcan Nasal Spray Clinical Trials
See Literature
Narcan Nasal Spray Note
Not Applicable
Narcan Nasal Spray Patient Counseling
See Literature
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