Namenda Xr

  • Alzheimer's dementia

Namenda Xr Generic Name & Formulations

General Description

Memantine HCl 7mg, 14mg, 21mg, 28mg; ext-rel caps.

Pharmacological Class

NMDA receptor antagonist.

How Supplied

Tabs—60; Titration Pak (28 x 5mg + 21 x 10mg)—1; Oral soln—contact supplier; XR caps 7mg, 21mg—30; 14mg, 28mg—30, 90; XR Titration Pak (7 x 7mg + 7 x 14mg + 7 x 21mg + 7 x 28mg)—1


Generic Availability


Namenda Xr Indications


Moderate-to-severe dementia of the Alzheimer's type.

Namenda Xr Dosage and Administration


Do not divide doses. Swallow whole or may open caps and sprinkle on applesauce, then consume entire contents. Initially 7mg once daily; titrate at intervals of at least 1 week in increments of 7mg to target dose of 28mg once daily. Max 28mg once daily. Severe renal impairment (CrCl 5–29mL/min): titrate to target dose of 14mg/day. Switching from immediate-release tabs: give XR caps the day after last dose of immediate-release tabs; see full labeling.


Not established.

Namenda Xr Contraindications

Not Applicable

Namenda Xr Boxed Warnings

Not Applicable

Namenda Xr Warnings/Precautions


Severe hepatic impairment. Alkalinized urine (eg, renal tubular acidosis, severe UTI) increases memantine serum levels. Seizure disorder. Pregnancy. Nursing mothers.

Namenda Xr Pharmacokinetics


Hepatic (partial).


Renal. Half-life: ~60–80 hours.

Namenda Xr Interactions


Caution with other NMDA antagonists (eg, amantadine, ketamine, dextromethorphan). May affect or be affected by renally-excreted drugs (eg, triamterene, HCTZ, metformin, cimetidine, nicotine, ranitidine, quinidine). Plasma levels may be increased by urinary alkalinizers.

Namenda Xr Adverse Reactions

Adverse Reactions

Headache, dizziness, confusion, diarrhea, constipation, hypertension, pain, somnolence, hallucination, urinary disorders, dyspnea.

Namenda Xr Clinical Trials

See Literature

Namenda Xr Note

Not Applicable

Namenda Xr Patient Counseling

See Literature