Indications for Naloxone HCl:

Reversal of opioid depression, including respiratory. Diagnosis of acute opioid overdose.


See full labeling. Post-op: 0.1–0.2mg IV, IM or SC, repeat 2–3 mins until desired response. Overdose: 0.4–2mg IV, IM or SC, repeat 2–3 mins; if no response after 10mg reevaluate. Both may require repeated doses depending on duration of narcotic activity.


See full labeling. Post-op: 0.005–0.01mg/kg IV, IM or SC, repeat 2–3 mins until desired response. Overdose: 0.01mg/kg initially; if inadequate response give 0.1mg/kg body weight. Neonates, post-op: 0.01mg/kg, repeat 2–3 mins until desired response.


Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Renal or hepatic insufficiency. Elderly. Pregnancy (Cat.C). Nursing mothers.

Pharmacologic Class:

Opioid antagonist.


Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.

Adverse Reactions:

Reversal of opioid depression: nausea, vomiting, sweating, tachycardia, increase BP, tremulousness, seizures, ventricular tacychardia and fibrillation, pulmonary edema, cardiac arrest. Also, excessive naloxone doses in post-op: reversal of analgesia, agitation.


Formerly known under the brand name Narcan.

How Supplied:

Contact supplier.