Naloxone Hcl

  • Poisoning/overdose

Naloxone Hcl Generic Name & Formulations

General Description

Naloxone 0.4mg/mL, 1mg/mL; IV, IM or SC inj; amps (paraben-free); vials.

Pharmacological Class

Opioid antagonist.

How Supplied

Contact supplier.

Naloxone Hcl Indications


Reversal of opioid depression, including respiratory. Diagnosis of acute opioid overdose.

Naloxone Hcl Dosage and Administration


See full labeling. Post-op: 0.1–0.2mg IV, IM or SC, repeat 2–3 mins until desired response. Overdose: 0.4–2mg IV, IM or SC, repeat 2–3 mins; if no response after 10mg reevaluate. Both may require repeated doses depending on duration of narcotic activity.


See full labeling. Post-op: 0.005–0.01mg/kg IV, IM or SC, repeat 2–3 mins until desired response. Overdose: 0.01mg/kg initially; if inadequate response give 0.1mg/kg body weight. Neonates, post-op: 0.01mg/kg, repeat 2–3 mins until desired response.

Naloxone Hcl Contraindications

Not Applicable

Naloxone Hcl Boxed Warnings

Not Applicable

Naloxone Hcl Warnings/Precautions


Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in pre-existing cardiac disease. Have other resuscitative measures available. Renal or hepatic insufficiency. Elderly. Pregnancy (Cat.C). Nursing mothers.

Naloxone Hcl Pharmacokinetics

See Literature

Naloxone Hcl Interactions


Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.

Naloxone Hcl Adverse Reactions

Adverse Reactions

Reversal of opioid depression: nausea, vomiting, sweating, tachycardia, increase BP, tremulousness, seizures, ventricular tacychardia and fibrillation, pulmonary edema, cardiac arrest. Also, excessive naloxone doses in post-op: reversal of analgesia, agitation.

Naloxone Hcl Clinical Trials

See Literature

Naloxone Hcl Note


Formerly known under the brand name Narcan.

Naloxone Hcl Patient Counseling

See Literature