Nalmefene Hydrochloride Injection Generic Name & Formulations
Nalmefene hydrochloride 1mg/mL (equivalent to 1mg nalmefene base); per vial; soln for IV, IM, or SC inj.
Single-dose vials (2mL)—10
Mechanism of Action
Nalmefene hydrochloride prevents or reverses the effects of opioids, including respiratory depression, sedation, and hypotension.
Nalmefene Hydrochloride Injection Indications
Reversal of opioid drug effects, including respiratory depression, induced by either natural or synthetic opioids. Management of known or suspected opioid overdose.
Nalmefene Hydrochloride Injection Dosage and Administration
IV route preferable: see full labeling. Reversal of opioid effects: see full labeling. Suspected opioid overdose (non-opioid dependent): initially 0.5mg/70kg, may follow with 2nd dose of 1mg/70kg if needed, 2–5mins later; do not give additional doses if no response after a total dose of 1.5mg/70kg. If opioid dependency suspected, may use an initial challenge of 0.1mg/70kg; if no evidence of withdrawal in 2mins, administer 0.5mg/70kg. Renal failure: give incremental doses more slowly (over 60secs).
Nalmefene Hydrochloride Injection Contraindications
Nalmefene Hydrochloride Injection Boxed Warnings
Nalmefene Hydrochloride Injection Warnings/Precautions
Risk of recurrent respiratory depression. Cardiovascular disease or risk. Known or suspected opioid dependence. Caution when administering after high doses of opioids. Seizure disorders. Elderly. Pregnancy. Nursing mothers.
Nalmefene Hydrochloride Injection Pharmacokinetics
Renal (major), fecal (17%). Half-life: 10.8 ± 5.2 hours.
Nalmefene Hydrochloride Injection Interactions
Caution with concomitant cardiotoxic drugs. Incomplete reversal of buprenorphine. Possible risk of seizures with flumazenil.
Nalmefene Hydrochloride Injection Adverse Reactions
Nausea, vomiting, tachycardia, hypertension, post-op pain, fever, dizziness, headache, chills, hypotension, vasodilation; acute withdrawal symptoms.
Nalmefene Hydrochloride Injection Clinical Trials
Nalmefene Hydrochloride Injection Note
Formerly known under the brand name Revex.
Nalmefene Hydrochloride Injection Patient Counseling