Arthritis/rheumatic disorders:

Indications for: Nabumetone

Rheumatoid arthritis. Osteoarthritis.

Adult Dosage:

Initially 1g once daily; max 2g/day in 1 or 2 divided doses. Renal insufficiency (CrCl 30–49mL/min): initial max 750mg once daily, may increase to 1.5g/day; (CrCl <30mL/min): initial max 500mg once daily, may increase to 1g/day.

Children Dosage:

Not recommended.

Nabumetone Contraindications:

Aspirin allergy. 3rd trimester pregnancy. Coronary artery bypass graft surgery.

Nabumetone Warnings/Precautions:

Advanced renal disease: not recommended. History of upper GI disease or other ulcer risk. Cardiovascular disease. Renal or severe hepatic impairment. Fluid retention. Heart failure. Hypertension. Asthma. Monitor BP, renal and hepatic function. Discontinue if hepatic dysfunction or skin rash occurs. Monitor hemoglobin or hematocrit if signs of anemia occur. Avoid sun, UV light. Elderly. Debilitated. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Nabumetone Classification:

NSAID (naphthylalkanone).

Nabumetone Interactions:

Renal toxicity potentiated with diuretics. May potentiate lithium. May antagonize ACE inhibitors. Monitor oral anticoagulants (eg, warfarin). Caution with methotrexate.

Adverse Reactions:

GI bleeding or upset, edema, photosensitivity, dry mouth, dizziness, headache, fatigue, sweating, insomnia, nervousness, somnolence, rash (discontinue if occurs), pruritus, tinnitus. See literature re: risk of cardiovascular events.


Formerly known under the brand name Relafen.

How Supplied:

Contact supplier

Pricing for Nabumetone

500mg tablet (Qty: 60)
Appx. price $15