• Seizure disorders

Mysoline Generic Name & Formulations

General Description

Primidone 50mg, 250mg; scored tabs.

Pharmacological Class


How Supplied

Tabs 50mg—100, 500; 250mg—100, 1000

Mysoline Indications


Tonic-clonic, focal and psychomotor seizures.

Mysoline Dosage and Administration


Initially: 100–125mg at bedtime. Increase every 3 days if needed by 100–125mg daily to 3 times daily on day 7. On day 10, increase to 250mg 3 times daily; max 2g daily in divided doses.


<8yrs: initially 50mg at bedtime. On day 4, increase if needed to 50mg twice daily. On day 7, to 100mg twice daily. On day 10, to 125–250mg 3 times daily. Usual maintenance: 100–250mg 3 times daily or 10–25mg/kg/day in divided doses. ≥8yrs: as adult.

Mysoline Contraindications


Porphyria. Barbiturate hypersensitivity.

Mysoline Boxed Warnings

Not Applicable

Mysoline Warnings/Precautions


Impaired liver function. Change dose gradually. Monitor blood counts, electrolytes. Pregnancy. Nursing mothers.

Mysoline Pharmacokinetics

See Literature

Mysoline Interactions


Potentiated with alcohol and other CNS depressants. Antagonizes oral anticoagulants and contraceptives, steroids, Vit. K and D, griseofulvin, doxycycline. Variable effects with phenytoin, valproic acid, divalproex. Potentiated by MAOIs. Antagonizes tricyclic antidepressants.

Mysoline Adverse Reactions

Adverse Reactions

Drowsiness, ataxia, dizziness, nystagmus, neonatal hemorrhage and withdrawal, nausea, vomiting, rash, megaloblastic anemia sensitive to folic acid, emotional disorders, impotence.

Mysoline Clinical Trials

See Literature

Mysoline Note

Not Applicable

Mysoline Patient Counseling

See Literature