Overactive bladder/enuresis:
Indications for MYRBETRIQ:
Treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, as monotherapy or in combination with solifenacin.
Adult:
Swallow whole. Initially 25mg once daily; may increase to 50mg once daily as needed or tolerated. Severe renal impairment or moderate hepatic impairment: max 25mg once daily. ESRD or severe hepatic impairment: not recommended.
Children:
Not established.
Warnings/Precautions:
Severe uncontrolled hypertension: not recommended. Monitor blood pressure periodically. Significant bladder outlet obstruction, patients taking antimuscarinic drugs for OAB: risk of urinary retention. Discontinue and treat if angioedema of the tongue, hypopharynx, or larynx occurs. Pregnancy. Nursing mothers.
Pharmacologic Class:
Beta-3 adrenergic agonist.
Interactions:
May potentiate CYP2D6 substrates (eg, metoprolol, desipramine); adjust dose and monitor esp. with narrow therapeutic index drugs (eg, thioridazine, flecainide, propafenone). Concomitant digoxin: use lowest digoxin dose initially (monitor and titrate).
Adverse Reactions:
Hypertension, nasopharyngitis, urinary tract infection, headache; also with solifenacin: dry mouth, constipation, tachycardia; angioedema.
Elimination:
Renal, fecal.
Generic Availability:
NO
How Supplied:
Tabs—30, 90
