Myrbetriq Granules

  • Overactive bladder/enuresis

Myrbetriq Granules Generic Name & Formulations

General Description

Mirabegron 8mg/mL; for ext-rel oral susp after reconstitution; contains mannitol.

Pharmacological Class

Beta-3 adrenergic agonist.

See Also

How Supplied

Tabs—30, 90; Granules—1

Generic Availability


Myrbetriq Granules Indications


Neurogenic detrusor overactivity (NDO) in pediatric patients aged ≥3yrs.

Myrbetriq Granules Dosage and Administration


Not indicated.


<3yrs: not established. Measure and dissolve granules with 100mL of water. Take with food once daily. ≥3yrs (11–<22kg): Initially 3mL (24mg), max 6mL (48mg); (22–<35kg): Initially 4mL (32mg), max 8mL (64mg); (≥35kg): Initially 6mL (48mg), may increase to max 10mL (80mg) after 4–8 weeks if needed. Severe renal impairment or moderate hepatic impairment: (11–<22kg): max 3mL (24mg); (22–<35kg): max 4mL (32mg); (≥35kg): max 6mL (48mg). ESRD, requiring dialysis, or severe hepatic impairment: not recommended.

Myrbetriq Granules Contraindications

Not Applicable

Myrbetriq Granules Boxed Warnings

Not Applicable

Myrbetriq Granules Warnings/Precautions


Do not substitute tabs and granules on a mg-per-mg basis. Severe uncontrolled hypertension: not recommended. Monitor blood pressure periodically. Significant bladder outlet obstruction, patients taking antimuscarinic drugs for OAB: risk of urinary retention. Discontinue and treat if angioedema of the tongue, hypopharynx, or larynx occurs. Pregnancy. Nursing mothers.

Myrbetriq Granules Pharmacokinetics

See Literature

Myrbetriq Granules Interactions


May potentiate CYP2D6 substrates (eg, metoprolol, desipramine); adjust dose and monitor esp. with narrow therapeutic index drugs (eg, thioridazine, flecainide, propafenone). Concomitant digoxin: use lowest digoxin dose initially (monitor and titrate).

Myrbetriq Granules Adverse Reactions

Adverse Reactions

Adults: hypertension, nasopharyngitis, UTI, headache; also with solifenacin: dry mouth, constipation, tachycardia. Children: UTI, nasopharyngitis, constipation, headache.

Myrbetriq Granules Clinical Trials

See Literature

Myrbetriq Granules Note

Not Applicable

Myrbetriq Granules Patient Counseling

See Literature