Pituitary disorders:

Indications for MYCAPSSA:

Long-term maintenance treatment in acromegaly patients who have responded to and tolerated treatment with octreotide or lanreotide.

Adult:

Swallow whole. Take on an empty stomach (≥1hr before or ≥2hrs after a meal). Initially 20mg twice daily; titrate and increase in 20mg increments, based on IGF-1 levels and response; max 80mg/day. Dose interruptions/modifications: see full labeling. ESRD: initially 20mg once daily.

Children:

Not established.

Warnings/Precautions:

Diabetes. Thyroid function abnormalities. Assess thyroid function periodically. Cardiac conduction abnormalities. Monitor gallbladder, glucose, vitamin B12 levels. Discontinue and treat if cholelithiasis complications are suspected. Monitor IGF-1 levels every 2 weeks during dose titration and monthly when maintenance dose is achieved, or as indicated. ESRD (see Adult dose). Liver cirrhosis. Fatty liver disease. Elderly. Pregnancy. Nursing mothers.

Pharmacologic Class:

Somatostatin analogue.

Interactions:

Concomitant bradycardia-inducing drugs (eg, β-blockers, calcium channel blockers); may need dose adjustments. Potentiates bromocriptine, CYP450 substrates (eg, quinidine), lisinopril; monitor and adjust dose if needed. Antagonized by PPIs, H2-receptor antagonists, or antacids; may need increased dose of Mycapssa. Antagonizes cyclosporine (adjust dose), digoxin (monitor). Antagonizes levonorgestrel (advise to use alternative non-hormonal contraceptive or back-up method). May need to adjust insulin or antidiabetic agents.

Adverse Reactions:

Nausea, diarrhea, headache, arthralgia, asthenia, hyperhidrosis, peripheral swelling, increased blood glucose, vomiting, abdominal discomfort, dyspepsia, sinusitis, osteoarthritis; gallbladder abnormalities/sludge, hyperglycemia, hypoglycemia, hypothyroidism, cardiac conduction abnormalities, ECG changes, abnormal Schilling's tests.

Generic Availability:

NO

How Supplied:

Caps—28

Pricing for MYCAPSSA

28 capsules of 20mg package (Qty: 1)
Appx. price $2637
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