Muse Generic Name & Formulations
Alprostadil 250mcg, 500mcg, 1000mcg; urethral suppository.
Mechanism of Action
Alprostadil (PGE1) has been shown to cause dose-dependent smooth muscle relaxation in isolated corpus cavernosum and corpus spongiosum preparations. The vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arterial inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through subtunical vessels is impeded and penile rigidity develops. This process is referred to as the corporal veno-occlusive mechanism.
Muse Dosage and Administration
Supervise titration. Initially 125–250mcg inserted in urethra after urination; adjust dose in stepwise manner on separate occasions; max 2 supps/day.
Urethral stricture. Balanitis. Severe hypospadias and curvature. Acute or chronic urethritis. Predisposition to venous thrombosis (eg, sickle cell anemia or trait). Hyperviscosity syndrome. Patients for whom sexual activity is inadvisable or contraindicated. If partner is pregnant, use condom; if partner is of childbearing age, use contraception.
Muse Boxed Warnings
Exclude reversible causes. Hypotension. Bleeding disorders. Priapism. Pregnancy (Cat.C): see Contraindications.
Renal. Half-life: 0.5–10 minutes.
Effect attenuated by drugs that interfere with erectile function (eg, decongestants). Caution with anticoagulants.
Muse Adverse Reactions
Penile, urethral, or testicular pain, urethral burning, minor urethral bleeding/spotting, dizziness, hypotension, flu symptoms, rhinitis, others. Infrequent: priapism. Partners: vaginal burning/itching.
Muse Clinical Trials
Muse Patient Counseling