• Diarrhea

Motofen Generic Name & Formulations

General Description

Difenoxin HCl 1mg, atropine sulfate 0.025mg; tabs.

Pharmacological Class

Opioid + anticholinergic.

How Supplied

Tabs—50, 100

Motofen Indications


Adjunctive therapy in the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea.

Motofen Dosage and Administration


Initially 2mg, then 1mg after each loose stool or 1mg every 3–4 hours as needed. Max 8mg/24hrs. Discontinue use if no improvement after 48hrs.


Not recommended.

Motofen Contraindications


Diarrhea associated with organisms that penetrate the intestinal mucosa (eg, toxigenic E. coli, Salmonella species, Shigella) and pseudomembranous colitis associated with broad spectrum antibiotics. Children <2yrs old. Jaundice.

Motofen Boxed Warnings

Not Applicable

Motofen Warnings/Precautions


Monitor fluid and electrolyte balance. Withhold dose if severe dehydration or electrolyte imbalance occurs. Acute ulcerative colitis; discontinue if abdominal distention occurs or if other untoward symptoms develop. Advanced hepatorenal disease or abnormal liver function tests; hepatic coma may be precipitated. Children with Down's syndrome. Pregnancy (Cat.C). Nursing mothers: not recommended.

Motofen Pharmacokinetics

See Literature

Motofen Interactions


Avoid in patients in whom anticholinergic drugs are contraindicated. Hypertensive crisis possible with concomitant MAOIs. May potentiate barbiturates, tranquilizers, narcotics, alcohol; monitor.

Motofen Adverse Reactions

Adverse Reactions

GI upset, dry mouth, epigastric distress, constipation, dizziness, drowsiness, headache, tiredness, nervousness, insomnia, confusion.

Motofen Clinical Trials

See Literature

Motofen Note

Not Applicable

Motofen Patient Counseling

See Literature