• Acne

Minolira Generic Name & Formulations

General Description

Minocycline HCl 105mg, 135mg; ext-rel tabs; scored.

Pharmacological Class

Tetracycline antibiotic.

How Supplied

Ext-rel tabs—30


Generic Availability


Minolira Indications


Inflammatory lesions of non-nodular moderate to severe acne vulgaris.

Minolira Dosage and Administration


Swallow whole. Give approximately 1mg/kg once daily for 12wks. Weight-based dosing (45–59kg): 52.5mg; (60–89kg): 67.5mg; (90–125kg): 105mg; (126–136kg): 135mg. Renal impairment: reduce dose or extend dosing intervals.


<12yrs: not established.

Minolira Contraindications

Not Applicable

Minolira Boxed Warnings

Not Applicable

Minolira Warnings/Precautions


Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal or hepatic impairment. Avoid sun or UV light. Pregnancy, nursing mothers: not recommended.

Minolira Pharmacokinetics

See Literature

Minolira Interactions


Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. May interfere with fluorescence test.

Minolira Adverse Reactions

Adverse Reactions

Headache, fatigue, dizziness, pruritus, malaise; teeth discoloration, delayed skeletal development, intracranial hypertension, CNS effects, C.difficile-associated diarrhea, photosensitivity, increased BUN, hepatotoxicity, renal toxicity, hyperpigmentation, skin/hypersensitivity reactions (may be severe), lupus-like syndrome, serum sickness-like syndrome.

Minolira Clinical Trials

See Literature

Minolira Note

Not Applicable

Minolira Patient Counseling

See Literature