• Hypotension

Midodrine Generic Name & Formulations

General Description

Midodrine HCl 2.5mg, 5mg, 10mg; scored tabs.

Pharmacological Class

Alpha-1 agonist.

How Supplied

Contact supplier.

Midodrine Indications


Symptomatic orthostatic hypotension.

Midodrine Dosage and Administration


Take during the day while upright; allow at least 4 hours between last dose and bedtime. 10mg 3 times daily at 3–4 hour intervals. Renal dysfunction: initially 2.5mg 3 times daily. Discontinue if no improvement after initial therapy.


Not established.

Midodrine Contraindications


Severe heart disease. Acute renal disease. Urinary retention. Pheochromocytoma. Thyrotoxicosis. Persistent, excessive supine hypertension.

Midodrine Boxed Warnings

Not Applicable

Midodrine Warnings/Precautions


Initial supine systolic pressure >180mmHg: not recommended. Monitor supine and sitting BP. Discontinue if supine hypertension occurs. Diabetes. Renal or hepatic impairment. Pregnancy (Cat.C). Nursing mothers.

Midodrine Pharmacokinetics

See Literature

Midodrine Interactions


Avoid concomitant drugs that increase BP (eg, phenylephrine, pseudoephedrine, ephedrine, dihydroergotamine, thyroid hormones, droxidopa); if unavoidable, monitor BP closely. Avoid concomitant MAO inhibitors or linezolid. Potentiated by sodium-retaining steroids (eg, fludrocortisone acetate); caution in increased intraocular pressure with fludrocortisone. Antagonized by α-antagonists (eg, prazosin, terazosin, doxazosin). Levels may be affected by renally-excreted alkaline drugs (eg, metformin, cimetidine, ranitidine, procainamide, triamterene, flecainide, quinidine). Cardiac glycosides, β-blockers, CNS drugs may cause bradycardia, AV block, arrhythmias; discontinue if bradycardia occurs.

Midodrine Adverse Reactions

Adverse Reactions

Paresthesia, piloerection, dysuria, pruritus, supine hypertension, chills, pain, rash.

Midodrine Clinical Trials

See Literature

Midodrine Note


Formerly known under the brand name Proamatine.

Midodrine Patient Counseling

See Literature