CHF and arrhythmias:

Indications for: Mexiletine

Documented life-threatening ventricular arrhythmias.

Adult Dosage:

Take with food or antacid. Initially 200mg every 8hrs when rapid control of arrhythmia is not essential. Adjust dose if needed at not less than 2–3 day intervals in 50–100mg increments. Usual dose: 200–300mg every 8hrs; max 1.2g/day. May increase to 400mg every 8hrs if unsatisfactory response. When rapid control of ventricular arrhythmia is essential: may give initial loading dose of 400mg, followed by 200mg after 8hrs. If adequate response is achieved by ≤300mg every 8hrs, may give same total daily dose in divided doses every 12hrs; up to max 450mg every 12hrs. For rapid induction, transferring from other antiarrhythmics: see full labeling.

Children Dosage:

Not established.

Mexiletine Contraindications:

Cardiogenic shock. 2nd- or 3rd- degree AV block unless paced.

Boxed Warning:

Mortality. Acute liver injury.

Mexiletine Warnings/Precautions:

Risk of mortality, acute liver injury. Evaluate if abnormal liver function tests or signs/symptoms suggesting liver dysfunction occur. Consider discontinuing if persistent or worsening elevation of hepatic enzymes is detected. Discontinue if drug reactions with eosinophilia and systemic symptoms (DRESS) is suspected. Preexisting sinus node dysfunction or intraventricular conduction abnormalities. Hypotension. Severe congestive heart failure. Seizure disorder. Monitor ECG, blood counts. If warranted, discontinue if significant hematologic changes are observed. Hepatic impairment. Pregnancy. Nursing mothers: not recommended; consider alternative infant feeding method if therapy is needed.

Mexiletine Classification:

Class IB antiarrhythmic.

Mexiletine Interactions:

May potentiate other antiarrhythmics, theophylline. Slowly titrate mexiletine dose to desired effect when concomitant propafenone. Monitor control if used with phenytoin or other hepatic enzyme-inducing drugs (eg, rifampin, phenobarbital). Monitor closely if used with cimetidine. Avoid drugs or diets that alter urinary pH.

Adverse Reactions:

Upper GI distress, dizziness/lightheadedness, tremor, nervousness, coordination difficulties, chest pain, palpitations, changes in sleep habits, blurred vision/visual disturbances, headache; acute liver injury, DRESS, blood dyscrasias.


Formerly known under the brand name Mexitil.

How Supplied:

Contact supplier.