Metronidazole Injection Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
See Also
How Supplied
Manufacturer
Mechanism of Action
Metronidazole Injection Indications
Indications
Metronidazole Injection Dosage and Administration
Adult
Children
Metronidazole Injection Contraindications
Contraindications
Metronidazole Injection Boxed Warnings
Not Applicable
Metronidazole Injection Warnings/Precautions
Warnings/Precautions
Metronidazole Injection Pharmacokinetics
Absorption
-
Disposition of metronidazole in the body is similar for both oral and intravenous dosage forms.
-
In patients treated with intravenous metronidazole, using a dosage regimen of 15 mg/kg loading dose followed 6 hours later by 7.5 mg/kg every 6 hours, the average peak steady-state plasma concentrations (Cmax) and trough concentrations (Cmin) were 25 mcg/mL and 18 mcg/mL, respectively.
-
Plasma concentrations of metronidazole are proportional to the administered dose. An eight-hour intravenous infusion of 100 mg to 4,000 mg of metronidazole in normal subjects showed a linear relationship between dose and peak plasma concentration.
Distribution
-
<20% is bound to plasma proteins.
-
Distributed in CSF, saliva, and breast milk at concentrations similar to those found in plasma.
-
Following a single intravenous dose of metronidazole 500 mg, 4 healthy subjects who underwent gastrointestinal endoscopy had peak gastric juice metronidazole concentrations of 5 to 6 mcg/mL at one hour post-dose.
Elimination
-
Renal (60% to 80% of the dose), fecal (6% to 15%).
-
Half-life: 8 hours.
Metronidazole Injection Interactions
Interactions
Metronidazole Injection Adverse Reactions
Adverse Reactions
Metronidazole Injection Clinical Trials
See Literature
Metronidazole Injection Note
Not Applicable