Select therapeutic use:

Edema:

Indications for Metolazone:

Edema.

Adult Dosage:

Individualize. 5–20mg once daily.

Children Dosage:

Not established.

Metolazone Contraindications:

Anuria. Hepatic coma or precoma.

Metolazone Warnings/Precautions:

Monitor fluids, electrolytes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if severe electrolyte imbalance develops rapidly. Diabetes. Gout. SLE. Sulfonamide allergy. Severe renal impairment: discontinue if azotemia and oliguria worsen. Pregnancy (Cat.B). Nursing mothers: not recommended.

Metolazone Classification:

Diuretic (quinazoline).

Metolazone Interactions:

Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. May antagonize methenamine. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. May be antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, barbiturates, narcotics, other antihypertensives. Monitor anticoagulants.

Adverse Reactions:

Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, chest or joint pain, rash (may be severe).

Note:

Formerly known under the brand name Zaroxolyn.

How Supplied:

Contact supplier

Pricing for Metolazone

2.5mg tablet (Qty: 30)
Appx. price $25
GoodRx

Hypertension:

Indications for Metolazone:

Hypertension.

Adult Dosage:

Individualize. 2.5–5mg once daily.

Children Dosage:

Not established.

Metolazone Contraindications:

Anuria. Hepatic coma or precoma.

Metolazone Warnings/Precautions:

Monitor fluids, electrolytes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if severe electrolyte imbalance develops rapidly. Diabetes. Gout. SLE. Sulfonamide allergy. Severe renal impairment: discontinue if azotemia and oliguria worsen. Pregnancy (Cat.B). Nursing mothers: not recommended.

Metolazone Classification:

Diuretic (quinazoline).

Metolazone Interactions:

Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. May antagonize methenamine. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. May be antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, barbiturates, narcotics, other antihypertensives. Monitor anticoagulants.

Adverse Reactions:

Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, chest or joint pain, rash (may be severe).

Note:

Formerly known under the brand name Zaroxolyn.

How Supplied:

Contact supplier

Pricing for Metolazone

2.5mg tablet (Qty: 30)
Appx. price $25
GoodRx