Share on Facebook
Share on Twitter
Share on LinkedIn
Share by Email
Print
Methyldopa/hydrochlorothiazide Tablets Generic Name & Formulations
Legal Class
Rx
General Description
Methyldopa, hydrochlorothiazide; 250mg/15mg, 250mg/25mg; tabs.
Pharmacological Class
Central alpha agonist + diuretic.
How Supplied
Contact supplier
Manufacturer
Methyldopa/hydrochlorothiazide Tablets Indications
Indications
Hypertension.
Methyldopa/hydrochlorothiazide Tablets Dosage and Administration
Adult
Titrate individual components. Initially one 250mg/15mg tab 2–3 times daily or one 250mg/25mg tab 2 times daily. Max 3g/day methyldopa and 50mg/day HCTZ.
Children
Not established.
Methyldopa/hydrochlorothiazide Tablets Contraindications
Contraindications
Active hepatic disease. Anuria. Sulfonamide allergy. History of methyldopa-associated liver dysfunction. Concomitant MAOIs.
Methyldopa/hydrochlorothiazide Tablets Boxed Warnings
Not Applicable
Methyldopa/hydrochlorothiazide Tablets Warnings/Precautions
Warnings/Precautions
History of hepatic dysfunction. Pheochromocytoma. Severe cerebrovascular or renal disease. SLE. Gout. Diabetes. Asthma. Edema. Dialysis. Postsympathectomy. Monitor blood, liver function, blood lipids, and electrolytes. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Methyldopa/hydrochlorothiazide Tablets Pharmacokinetics
See Literature
Methyldopa/hydrochlorothiazide Tablets Interactions
Interactions
MAOIs (see Contraindications). Alcohol, CNS depressants may increase orthostatic hypotension. May increase toxicity of diazoxide, digitalis and lithium. May antagonize oral hypoglycemics. Antagonized by NSAIDs, iron. May interfere with parathyroid tests.
Methyldopa/hydrochlorothiazide Tablets Adverse Reactions
Adverse Reactions
Hemolytic anemia, fever, jaundice, hepatic necrosis, granulocytopenia, fluid or electrolyte imbalance, blurred vision, sedation, headache, asthenia, orthostatic hypotension, bradycardia, GI upset, rash, nasal congestion, hyperprolactinemia, arthralgia, positive Coomb's test.
Methyldopa/hydrochlorothiazide Tablets Clinical Trials
See Literature
Methyldopa/hydrochlorothiazide Tablets Note
Notes
Formerly known under the brand name Aldoril.
Methyldopa/hydrochlorothiazide Tablets Patient Counseling
See Literature
