Methyldopa/hydrochlorothiazide Tablets

— THERAPEUTIC CATEGORIES —
  • Hypertension

Methyldopa/hydrochlorothiazide Tablets Generic Name & Formulations

General Description

Methyldopa, hydrochlorothiazide; 250mg/15mg, 250mg/25mg; tabs.

Pharmacological Class

Central alpha agonist + diuretic.

How Supplied

Contact supplier

Methyldopa/hydrochlorothiazide Tablets Indications

Indications

Hypertension.

Methyldopa/hydrochlorothiazide Tablets Dosage and Administration

Adult

Titrate individual components. Initially one 250mg/15mg tab 2–3 times daily or one 250mg/25mg tab 2 times daily. Max 3g/day methyldopa and 50mg/day HCTZ.

Children

Not established.

Methyldopa/hydrochlorothiazide Tablets Contraindications

Contraindications

Active hepatic disease. Anuria. Sulfonamide allergy. History of methyldopa-associated liver dysfunction. Concomitant MAOIs.

Methyldopa/hydrochlorothiazide Tablets Boxed Warnings

Not Applicable

Methyldopa/hydrochlorothiazide Tablets Warnings/Precautions

Warnings/Precautions

History of hepatic dysfunction. Pheochromocytoma. Severe cerebrovascular or renal disease. SLE. Gout. Diabetes. Asthma. Edema. Dialysis. Postsympathectomy. Monitor blood, liver function, blood lipids, and electrolytes. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Methyldopa/hydrochlorothiazide Tablets Pharmacokinetics

See Literature

Methyldopa/hydrochlorothiazide Tablets Interactions

Interactions

MAOIs (see Contraindications). Alcohol, CNS depressants may increase orthostatic hypotension. May increase toxicity of diazoxide, digitalis and lithium. May antagonize oral hypoglycemics. Antagonized by NSAIDs, iron. May interfere with parathyroid tests.

Methyldopa/hydrochlorothiazide Tablets Adverse Reactions

Adverse Reactions

Hemolytic anemia, fever, jaundice, hepatic necrosis, granulocytopenia, fluid or electrolyte imbalance, blurred vision, sedation, headache, asthenia, orthostatic hypotension, bradycardia, GI upset, rash, nasal congestion, hyperprolactinemia, arthralgia, positive Coomb's test.

Methyldopa/hydrochlorothiazide Tablets Clinical Trials

See Literature

Methyldopa/hydrochlorothiazide Tablets Note

Notes

Formerly known under the brand name Aldoril.

Methyldopa/hydrochlorothiazide Tablets Patient Counseling

See Literature