• Miscellaneous Ob/Gyn conditions

Methergine Generic Name & Formulations

General Description

Methylergonovine maleate 0.2mg; tabs.

Pharmacological Class

Ergot alkaloid.

How Supplied

Tabs—7, 12, 28, 100; Inj (1mL amps)—20

Generic Availability


Methergine Indications


Following delivery of the placenta, for routine management of uterine atony, hemorrhage, and subinvolution of the uterus. For control of uterine hemorrhage in the second stage of labor following delivery of the anterior shoulder.

Methergine Dosage and Administration


0.2mg 3–4 times a day in the puerperium for max 1 week.


Not established.

Methergine Contraindications


Hypertension. Toxemia. Pregnancy (Cat.C).

Methergine Boxed Warnings

Not Applicable

Methergine Warnings/Precautions


Avoid intra-arterial, periarterial injection. Coronary artery disease or risk factors; may be more susceptible to developing MI and infarction associated with methylergonovine-induced vasospasm. Sepsis. Obliterative vascular disease. Hepatic or renal disease. 2nd stage of labor. Nursing mothers: not recommended (wait at least 12hrs after last dose before initiating or resuming feeding).

Methergine Pharmacokinetics

See Literature

Methergine Interactions


Potentiated by vasoconstrictors, other ergot alkaloids, prostaglandins, beta-blockers. Potent CYP3A4 inhibitors (eg, macrolides, protease inhibitors, reverse transcriptase inhibitors, azole antifungals): not recommended. Use caution with less potent CYP3A4 inhibitors (eg, saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, clotrimazole). Antagonized by strong inducers of CYP3A4 (eg, nevirapine, rifampicin), anesthetics (eg, halothane, methoxyflurane). Antagonizes glyceryl trinitrate, other antianginal drugs.

Methergine Adverse Reactions

Adverse Reactions

Hypertension associated with seizure and/or headache, hypotension, abdominal pain, GI upset; rare: cardiovascular effects (eg, vasoconstriction, acute MI, transient chest pains).

Methergine Clinical Trials

See Literature

Methergine Note

Not Applicable

Methergine Patient Counseling

See Literature