Methergine Injection

  • Miscellaneous Ob/Gyn conditions

Methergine Injection Generic Name & Formulations

General Description

Methylergonovine maleate 0.2mg/mL; amp.

Pharmacological Class

Ergot alkaloid.

See Also

How Supplied

Tabs—7, 12, 28, 100; Inj (1mL amps)—20

Generic Availability


Methergine Injection Indications


Following delivery of the placenta, for routine management of uterine atony, hemorrhage, and subinvolution of the uterus. For control of uterine hemorrhage in the second stage of labor following delivery of the anterior shoulder.

Methergine Injection Dosage and Administration


IM: 0.2mg after delivery of the anterior shoulder, after delivery of the placenta, or during the puerperium; may be repeated as required at intervals of 2–4 hours. IV: 0.2mg given slowly over a period of no less than 60 seconds.


Not established.

Methergine Injection Contraindications


Hypertension. Toxemia. Pregnancy (Cat.C).

Methergine Injection Boxed Warnings

Not Applicable

Methergine Injection Warnings/Precautions


Avoid intra-arterial, periarterial injection. Coronary artery disease or risk factors; may be more susceptible to developing MI and infarction associated with methylergonovine-induced vasospasm. Sepsis. Obliterative vascular disease. Hepatic or renal disease. 2nd stage of labor. Nursing mothers: not recommended (wait at least 12hrs after last dose before initiating or resuming feeding).

Methergine Injection Pharmacokinetics

See Literature

Methergine Injection Interactions


Potentiated by vasoconstrictors, other ergot alkaloids, prostaglandins, beta-blockers. Potent CYP3A4 inhibitors (eg, macrolides, protease inhibitors, reverse transcriptase inhibitors, azole antifungals): not recommended. Use caution with less potent CYP3A4 inhibitors (eg, saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, clotrimazole). Antagonized by strong inducers of CYP3A4 (eg, nevirapine, rifampicin), anesthetics (eg, halothane, methoxyflurane). Antagonizes glyceryl trinitrate, other antianginal drugs.

Methergine Injection Adverse Reactions

Adverse Reactions

Hypertension associated with seizure and/or headache, hypotension, abdominal pain, GI upset; rare: cardiovascular effects (eg, vasoconstriction, acute MI, transient chest pains).

Methergine Injection Clinical Trials

See Literature

Methergine Injection Note

Not Applicable

Methergine Injection Patient Counseling

See Literature