Mesnex Injection

  • Cytoprotective and supportive care agents

Mesnex Injection Generic Name & Formulations

General Description

Mesna 100mg/mL; soln for IV inj after dilution; contains benzyl alcohol.

Pharmacological Class

Cytoprotective agent.

See Also

How Supplied

Tabs—10; Multidose vials—1, 10


Mesnex Injection Indications


Prophylactic agent in reducing the incidence of ifosfamide-induced hemorrhagic cystitis.

Limitations of Use

Not indicated to reduce the risk of hematuria due to other conditions (eg, thrombocytopenia).

Mesnex Injection Dosage and Administration


See full labeling. IV schedule: give as IV bolus inj in a dosage equal to 20% of the ifosfamide dose at the time of ifosfamide administration and 4 and 8hrs after each dose of ifosfamide; total daily dose is 60% the ifosfamide dose. IV and oral schedule: give as IV bolus inj in a dosage equal to 20% of the ifosfamide dose at the time of ifosfamide administration, followed by the tablets given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6hrs after each dose of ifosfamide; total daily dose is 100% of the ifosfamide dose. Repeat schedule on each day ifosfamide is given. If vomiting occurs within 2hrs of oral mesna, repeat dose or give IV mesna.


Not established.

Mesnex Injection Contraindications

Not Applicable

Mesnex Injection Boxed Warnings

Not Applicable

Mesnex Injection Warnings/Precautions


Monitor urine for the presence of hematuria each day prior to ifosfamide therapy; consider dose reduction or discontinue ifosfamide if severe hematuria occurs. Hypersensitivity to thiol compounds. Discontinue and treat if hypersensitivity or serious skin reactions (eg, SJS, TEN) occur. Maintain adequate hydration. Inj: avoid in premature neonates and low-birth weight infants. Elderly. Pregnancy: exclude status prior to initiation. Use effective contraception during and for 6 months (females) or 3 months (males w. female partners) after the last dose. Nursing mothers: not recommended (during and for 1 week after the last dose).

Mesnex Injection Pharmacokinetics

See Literature

Mesnex Injection Interactions


May cause false (+) ketones in nitroprusside sodium-based urine tests and ascorbic acid in Tillman's urine tests. May interfere with enzymatic CPK activity tests.

Mesnex Injection Adverse Reactions

Adverse Reactions

With ifosfamide: nausea, vomiting, constipation, leukopenia, fatigue, fever, anorexia, thrombocytopenia, anemia, granulocytopenia, diarrhea, asthenia, abdominal pain, headache, alopecia, somnolence.

Mesnex Injection Clinical Trials

See Literature

Mesnex Injection Note


Patients taking mesna should drink at least a quart of liquid a day.

Mesnex Injection Patient Counseling

See Literature