Mepron Generic Name & Formulations
Atovaquone 750mg/5mL; oral susp; citrus flavor.
Treatment of mild-to-moderate Pneumocystis jirovecii pneumonia (PCP) in patients intolerant to trimethoprim/sulfamethoxazole (TMP/SMX). Prevention of PCP in patients intolerant to TMP/SMX.
Limitations of Use
Treatment of more severe PCP has not been studied. Mepron's efficacy has not been studied in those who are failing therapy with TMP/SMX.
Mepron Dosage and Administration
Take with food. ≥13yrs: Treatment: 750mg twice daily for 21 days. Prophylaxis: 1500mg once daily.
<13yrs: not established.
Mepron Boxed Warnings
GI disorders or inability to take with food. Monitor in severe hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers.
Concomitant rifampin or rifabutin: not recommended. Antagonized by tetracycline; caution and monitor if use is needed. May be antagonized by metoclopramide (use only if other antiemetics are not available). Antagonizes indinavir; caution and monitor if use is needed.
Mepron Adverse Reactions
Diarrhea, rash, headache, nausea, fever, rhinitis, vomiting, sweating, flu syndrome, sinusitis, pruritus, insomnia, depression, myalgia.
Mepron Clinical Trials
Mepron Patient Counseling