Mephyton Generic Name & Formulations
Phytonadione (Vit. K1) 5mg; scored tabs.
Anticoagulant-induced hypoprothrombinemia. Secondary hypoprothrombinemia. Other drug-induced hypoprothrombinemia.
Mephyton Dosage and Administration
See full labeling. Initially 2.5–25mg as a single dose depending on severity and response; max 50mg.
Mephyton Boxed Warnings
Does not counteract effects of heparin. Thromboembolism. Hepatic disease. Absorption requires endogenous bile supply. Elderly. Premature infants. Pregnancy. Nursing mothers.
May induce temporary resistance to prothrombin-depressing anticoagulants.
Mephyton Adverse Reactions
Transient flushing sensations, peculiar sensations of taste, instances of dizziness, rapid/weak pulse, profuse sweating, brief hypotension, dyspnea, cyanosis; hypersensitivity reactions, hyperbilirubinemia (w. high doses).
Mephyton Clinical Trials
Mephyton Patient Counseling