Memantine Oral Solution

  • Alzheimer's dementia

Memantine Oral Solution Generic Name & Formulations

General Description

Memantine HCl 2mg/mL; sugar-and alcohol-free; peppermint flavor.

Pharmacological Class

NMDA receptor antagonist.

How Supplied

Tabs—60; Titration Pak (28 x 5mg + 21 x 10mg)—1; Oral soln—contact supplier; XR caps 7mg, 21mg—30; 14mg, 28mg—30, 90; XR Titration Pak (7 x 7mg + 7 x 14mg + 7 x 21mg + 7 x 28mg)—1

Generic Availability


Memantine Oral Solution Indications


Moderate-to-severe dementia of the Alzheimer's type.

Memantine Oral Solution Dosage and Administration


Initially 5mg once daily; titrate at intervals of at least 1 week to 5mg twice daily, then to 5mg and 10mg as separate doses, then to 10mg twice daily (prescribe Titration Pak for 1st 4 weeks). Severe renal impairment (CrCl 5–29mL/min): titrate to max 5mg twice daily.


Not established.

Memantine Oral Solution Contraindications

Not Applicable

Memantine Oral Solution Boxed Warnings

Not Applicable

Memantine Oral Solution Warnings/Precautions


Severe hepatic impairment. Alkalinized urine (eg, renal tubular acidosis, severe UTI) increases memantine serum levels. Seizure disorder. Pregnancy. Nursing mothers.

Memantine Oral Solution Pharmacokinetics

See Literature

Memantine Oral Solution Interactions


Caution with other NMDA antagonists (eg, amantadine, ketamine, dextromethorphan). May affect or be affected by renally-excreted drugs (eg, triamterene, HCTZ, metformin, cimetidine, nicotine, ranitidine, quinidine). Plasma levels may be increased by urinary alkalinizers.

Memantine Oral Solution Adverse Reactions

Adverse Reactions

Headache, dizziness, confusion, diarrhea, constipation, hypertension, pain, somnolence, hallucination, urinary disorders, dyspnea.

Memantine Oral Solution Clinical Trials

See Literature

Memantine Oral Solution Note

Not Applicable

Memantine Oral Solution Patient Counseling

See Literature